Biofilm Production by Uropathogens in Postmenopausal Women With Recurrent and Isolated Urinary Tract Infection
Autor: | Kerac N Falk, Gina M. Northington, François Chassagne, Sarah W Satola, Cassandra L. Quave |
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Rok vydání: | 2022 |
Předmět: |
education.field_of_study
medicine.medical_specialty Pelvic floor business.industry Urology Urinary system Population Biofilm Obstetrics and Gynecology Odds ratio General Medicine urologic and male genital diseases Urogynecology medicine.anatomical_structure Internal medicine Cohort medicine Surgery education business Body mass index |
Zdroj: | Obstetrical & Gynecological Survey. 77:470-471 |
ISSN: | 1533-9866 0029-7828 |
Popis: | Objectives The aims of this study were to assess the in vitro biofilm-producing capabilities of uropathogens grown from a postmenopausal urogynecologic population with isolated and recurrent urinary tract infection (UTI) and to determine whether the biofilm-producing bacterial phenotype was associated with recurrent infection. Methods This was an institutional review board-approved cross-sectional analysis within a large academic referral center. Uropathogens were cultured from postmenopausal women with either isolated or recurrent acute UTI and then screened for in vitro biofilm formation using crystal violet microtiter assays. Demographic and clinical variables, including pelvic floor symptoms and surgical history were collected and analyzed. A multivariate model was developed to determine whether recurrent UTI was independently associated with biofilm production. Results Eighty-nine women were included: 67.4% White, 25.8% Black, 3.4% Asian, and 1.1% Hispanic with a mean age of 72 ± 10.5 years. Ninety-five uropathogen strains were isolated. Most uropathogens produced biofilm (n = 53, 55.8%). Uropathogens from women with recurrent UTI were significantly more likely to produce biofilm (70%) than uropathogens collected from women with isolated UTI (38.6%, P = 0.0033). Adjusting for age, prior pelvic reconstructive surgery, and body mass index, recurrent UTI bacteria were more likely to produce biofilm, compared with isolated UTI (odds ratio, 5.37; 95% confidence interval, 2.0-14.4; P = 0.001). Conclusions In this cohort of postmenopausal urogynecology patients, in vitro biofilm formation was more frequently observed in uropathogens isolated from women with recurrent UTI compared with women with isolated UTI. Further study is needed to assess the role of biofilms in recurrent UTIs in postmenopausal women. |
Databáze: | OpenAIRE |
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