Frontotemporal dementia patients exhibit deficits in predictive saccades
| Autor: | Jean Christophe Bier, Kurt Segers, Adrian Ivanoiu, Philippe Lefèvre, Demet Yüksel, Jean-Jacques Orban de Xivry, Nicolas Deravet |
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| Přispěvatelé: | UCL - SSS/IONS/COSY - Systems & cognitive Neuroscience, UCL - SSS/IONS/NEUR - Clinical Neuroscience, UCL - (SLuc) Service de neurologie, UCL - (SLuc) Service d'ophtalmologie |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Neurology Cognitive Neuroscience Models Neurological C9ORF72 Context (language use) 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Saccades Medicine Dementia Humans Timing Aged business.industry Predictive saccade Eye movement FTD medicine.disease Anticipation Sensory Systems Frontal Lobe Eye movements 030104 developmental biology Frontal lobe Saccade Frontotemporal Dementia Time processing Prediction business Neuroscience Frontotemporal dementia 030217 neurology & neurosurgery |
| Zdroj: | Journal of computational neuroscience, (2020) |
| ISSN: | 1573-6873 |
| Popis: | Prediction and time estimation are all but required for motor function in everyday life. In the context of eye movements, for instance, they allow predictive saccades and eye re-acceleration in anticipation of a target re-appearance. While the neural pathways involved are not fully understood, it is known that the frontal lobe plays an important role. As such, neurological disorders that affect it, such as frontotemporal (FTD) dementia, are likely to induce deficits in such movements. In this work, we study the performances of frontotemporal dementia patients in an oculomotor task designed to elicit predictive saccades at different rates, and compare them to young and older adults. Clear deficits in the production of predictive saccades were found in patients, in particular when the time between saccades was short (~500 ms). Furthermore, one asymptomatic C9ORF72 mutation bearer showed patterns of oculomotor behavior similar to FTD patients. He exhibited FTD symptoms within 3 years post-measure, suggesting that an impairment of oculomotor function could be an early clinical sign. Taken together, these results argue in favor of a role of the frontal lobe in predictive movements timing over short timescales, and suggest that predictive saccades in FTD patients warrant further investigation to fully assess their potential as a diagnostic aid. |
| Databáze: | OpenAIRE |
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