The effect of cigarette smoking on the development of AIDS in HIV-1-seropositive individuals
| Autor: | Richard Coker, J. R. W. Harris, D M Mitchell, R. B. Nieman, J Fleming |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Adult
Male Sexually transmitted disease medicine.medical_specialty Time Factors Epidemiologic Factors Opportunistic infection Immunology Acquired immunodeficiency syndrome (AIDS) Internal medicine HIV Seropositivity London medicine Humans Immunology and Allergy Outpatient clinic Life Tables Sida Acquired Immunodeficiency Syndrome biology business.industry Smoking Middle Aged biology.organism_classification medicine.disease respiratory tract diseases Pneumonia Infectious Diseases HIV-1 Female Viral disease business Complication |
| Zdroj: | AIDS. 7:705-710 |
| ISSN: | 0269-9370 |
| DOI: | 10.1097/00002030-199305000-00015 |
| Popis: | Objective To determine whether HIV-1-seropositive cigarette smokers progress more rapidly to AIDS than HIV-1-seropositive non-smokers. Setting The genitourinary medicine outpatient department of St Mary's Hospital, London, which is a London University teaching hospital (tertiary care centre). Subjects and design Case series of 84 individuals with AIDS who provided accurate details of their smoking habits before their AIDS-defining diagnosis. Main outcome measure Progression time to AIDS in relation to smoking habit. Results Progression time to AIDS (all diagnoses) was significantly reduced in HIV-1-seropositive smokers: median time to AIDS was 8.17 months for smokers (n = 43) and 14.50 months for non-smokers (n = 41) (P = 0.003). Smokers developed Pneumocystis carinii pneumonia (PCP) more rapidly than non-smokers, with a median time to PCP of 9.0 months, compared with 16.0 months for non-smokers (P = 0.002). Smoking had no significant effect on progression time to AIDS when not due to PCP. Conclusion Cigarette smoking by HIV-1-seropositive individuals is associated with a more rapid development of AIDS and should be discouraged. |
| Databáze: | OpenAIRE |
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