A 2-(benzothiazol-2-yl)-phenolato platinum(II) complex as potential photosensitizer for combating bacterial infections in lung cancer chemotherapy†

Autor: Begoña García, Natalia Busto, Christoph Janiak, José Ruiz, Cristina Pérez-Arnaiz, Venancio Rodríguez, Enrique Ortega
Rok vydání: 2021
Předmět:
Methicillin-Resistant Staphylococcus aureus
Platinum(II) complexes
Lung Neoplasms
Organoplatinum Compounds
medicine.medical_treatment
DMBA
Photodynamic therapy
Antineoplastic Agents
medicine.disease_cause
01 natural sciences
Chemistry
Physical and theoretical
03 medical and health sciences
Structure-Activity Relationship
Drug Discovery
medicine
Química física
Humans
Photosensitizer
Lung cancer
Photodynamic inhibition
030304 developmental biology
Pharmacology
0303 health sciences
Photosensitizing Agents
Dose-Response Relationship
Drug
Molecular Structure
010405 organic chemistry
Chemistry
Organic Chemistry
Dual action agents
Cancer
General Medicine
Bacterial Infections
medicine.disease
0104 chemical sciences
Anti-Bacterial Agents
Staphylococcus aureus
Cancer cell
Cancer research
Anticancer and antibacterial activity
Phototoxicity
Zdroj: Repositorio Institucional de la Universidad de Burgos (RIUBU)
Universidad de Burgos (UBU)
Universidad de Cantabria (UC)
Popis: Cancer and antibiotic resistance are two global health threats that usually hamper clinical chemotherapeutic efficacy. Particularly for lung cancer, bacterial infections frequently arise thereby complicating the course of cancer treatment. In this sense, three new neutral luminescent cycloplatinated(II) photosensitizers of the type [Pt(dmba)(L)] (dmba = N,N-dimethylbenzylamine-κN,κC; L = 2-(benzo[d]oxazol-2-yl)-phenolato-κN,κO 1, 2-(benzo[d]thiazol-2-yl)-phenolato-κN,κO 2, and 2-(1-methyl-1H-benzo[d]imidazole-2-yl)phenolato-κN,κO 3) have been characterized and developed to potentially eliminate both resistant bacteria and lung cancer cells. The phototherapeutic effects of complex 2 have been evaluated using low doses of blue light irradiation. Complex 2 exerted promising photoactivity against pathogenic Gram-positive bacteria strains of clinical interest, displaying a phototoxic index (PI) of 15 for methicillin-resistant Staphylococcus aureus, one of the major microorganisms predominating lung infections. Likewise, the anticancer activity of 2 was also increased upon light irradiation in human lung A549 cancer cells (PI = 36). Further in vitro experiments with this platinum(II) complex suggest that ROS-generating photodynamic reactions were involved upon light irradiation, thus providing a reasonable mechanism for its dual anticancer and antibacterial activities.
Spanish Ministerio de Ciencia e Innovación (MCI/AEI) and FEDER funds (Projects RTI2018-096891-B-I00, RTI2018-102040-B-100 and MultiMetDrugs network RED2018-102471-T), Consejería de Educación-Junta de Castilla y León-FEDER (BU042U16-BU305P18), “la Caixa” Banking Foundation (LCF/PR/PR12/11070003) and Fundación Séneca-Región de Murcia (Project 20857/PI/18). E.O. thanks AECC (PRDMU19003ORTE). Networking support by the COST Action CA18202
Databáze: OpenAIRE
Externí odkaz: