Density of breast: An independent risk factor for developing breast cancer, a prospective study at two premium breast centers

Autor:	Xin Lin Chin, Tuan Nur' Azmah Tuan Mat, Xin Ying Chai, Seniyah Mat Sikin, Chia Hwee Lo, Shirley Shy Wen Ting, Sze Chao Ang, Peeroo Saania, Anil Gandhi, Lay Teng Tan
Rok vydání:	2020
Předmět:	0301 basic medicine Oncology Cancer Research medicine.medical_specialty BI-RADS Breast Neoplasms lcsh:RC254-282 Risk Assessment 03 medical and health sciences breast cancer 0302 clinical medicine Breast cancer Risk Factors Internal medicine Humans Medicine Radiology Nuclear Medicine and imaging Prospective Studies Risk factor breast density skin and connective tissue diseases Prospective cohort study Early Detection of Cancer Original Research business.industry Malaysia Odds ratio Middle Aged lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens Prognosis medicine.disease 030104 developmental biology 030220 oncology & carcinogenesis Female Breast disease business Cancer Prevention Body mass index Tamoxifen Follow-Up Studies Mammography medicine.drug
Zdroj:	Cancer Medicine Cancer Medicine, Vol 9, Iss 9, Pp 3244-3251 (2020)
ISSN:	2045-7634
DOI:	10.1002/cam4.2821
Popis:	Background Breast cancer is the leading cause of death among women worldwide. Studies have identified breast density as a controversial risk factor of breast cancer. Moreover, studies found that breast density reduction through Tamoxifen could reduce risk of breast cancer significantly. To date, no study on the association between breast density and breast cancer has been carried out in Malaysia. If breast density is proven to be a risk factor of breast cancer, intervention could be carried out to reduce breast cancer risk through breast density reduction. Purpose To determine if density of breast is an independent risk factor which will contribute to development of breast cancer. Materials and Methods A prospective cohort study is carried out in two hospitals targeting adult female patients who presented to the Breast Clinic with symptoms suspicious of breast cancer. Participants recruited were investigated for breast cancer based on their symptoms. Breast density assessed from mammogram was correlated with tissue biopsy results and final diagnosis of benign or malignant breast disease. Results Participants with dense breasts showed 29% increased risk of breast cancer when compared to those with almost entirely fatty breasts (odds ratio [OR] 1.29, 95% CI 0.38‐4.44, P = .683). Among the postmenopausal women, those with dense breasts were 3.1 times more likely to develop breast cancer compared with those with fatty breasts (OR 3.125, 95% CI 0.72‐13.64, P = .13). Moreover, the chance of developing breast cancer increases with age (OR 1.046, 95% CI 1.003‐1.090, P There are many established risk factors of breast cancer, and density of breast is a controversial risk factor which we wanted to evaluate. Our study shows that postmenopausal women with dense breasts are 3 times more likely to develop breast cancer compared to those with low breast density.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9d7ccf3e578ae23ff677bdfad0c1634 https://doi.org/10.1002/cam4.2821 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.