Biomarkers of disease severity in patients with visceral leishmaniasis co-infected with HIV
| Autor: | Mariana Honda, Gabriel Reis Ferreira, Alda Maria Da-Cruz, Carlos Henrique Nery Costa, Maria Luciana Silva-Freitas, Joanna Reis Santos-Oliveira, Dorcas Lamounier Costa |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
CD4-Positive T-Lymphocytes Male Immunology Lipopolysaccharide Receptors HIV Infections Biochemistry Severity of Illness Index Virus Interferon-gamma Acquired immunodeficiency syndrome (AIDS) medicine Immunology and Allergy Humans Child Molecular Biology Univariate analysis business.industry Coinfection Interleukins Hematology medicine.disease Visceral leishmaniasis Concomitant Leishmaniasis Visceral Macrophage migration inhibitory factor Tumor necrosis factor alpha Female business Biomarkers |
| Zdroj: | Cytokine. 149 |
| ISSN: | 1096-0023 |
| Popis: | Visceral leishmaniasis (VL) is caused by the protozoan Leishmania spp, transmitted by sand fly bites. VL is one of the deadliest tropical infection diseases, yet the coinfection with HIV virus drastically increases relapses, treatment failure and mortality. The concomitant action of these two pathogens leads to high cellular activation independently of the progression to AIDS. In addition, microbial translocation and bacterial infections are thought to contribute worsening the clinical picture. Identifying biomarkers associated with disease severity is of interest for clinical management of patients with VL-HIV/AIDS. Thus, we analyzed in the sera several markers including interleukins (IL-1β, IL-6, IL-8, and IL-17), interferon-γ (IFN- γ), tumor necrosis factor (TNF), lipopolysaccharide (LPS), soluble CD14 (sCD14), macrophage migration inhibitory factor (MIF) and intestinal fatty acid-binding protein (IFABP). These markers were compared with disease severity in 24 patients with VL/HIV presenting different clinical outcomes. Disease severity was defined by the probability of death calculated using a score set system derived by the Kala-Cal® software. Probability of death ranged from 3.7% to 97.9%, with median of 28.8%. Five patients died (20%). At the univariate analysis, disease severity was correlated with TNF, IFN-γ and sCD14. LPS was positively correlated with sCD14 specifically in patients with low CD4+ count (CD4+ T-cell |
| Databáze: | OpenAIRE |
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