Urinary biotinidase and alanine excretion in patients with insulin-dependent diabetes mellitus
| Autor: | Ayako Tanae, Toshiaki Tanaka, Noriyuki Katsumata, Itsuro Hibi, Kou Hayakawa, Elena A. Terentyeva |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Urinary system education Clinical Biochemistry Urine Kidney Amidohydrolases Excretion Internal medicine Diabetes mellitus Acetylglucosaminidase medicine Albuminuria Humans Diabetic Nephropathies Biotinidase activity Child Chromatography High Pressure Liquid Alanine Chemistry Biotinidase Biochemistry (medical) Albumin Kidney metabolism General Medicine Middle Aged medicine.disease Proteinuria Endocrinology Diabetes Mellitus Type 1 Case-Control Studies Child Preschool Female |
| Zdroj: | European journal of clinical chemistry and clinical biochemistry : journal of the Forum of European Clinical Chemistry Societies. 35(1) |
| ISSN: | 0939-4974 |
| Popis: | Twenty-four-hour urine specimens from 21 juvenile insulin-dependent diabetics and 10 healthy controls were compared with respect to biotinidase activity and alanine content. Urinary biotinidase activity was analysed by a newly developed high-performance liquid chromatography (HPLC) method. It was found that the excretion of biotinidase in urine was elevated in diabetics (7.02 mU/d; p < 0.005) as compared with controls (not detectable). Alanine excretion was also found to increase (p < 0.01) in diabetics. Biotinidase excretion in diabetics was correlated with alanine excretion (rS = 0.667; p < 0.01), but not with protein, albumin or N-acetyl-beta-glucosaminidase excretion. The simultaneous elevation of urinary biotinidase and alanine excretion in juvenile diabetics suggests that changes in kidney metabolism arise in the early stages of diabetes. |
| Databáze: | OpenAIRE |
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