Effect of Dietary Polyphenon E and EGCG on Lung Tumorigenesis in A/J Mice
| Autor: | Qi Zhang, Jing Pan, Ronald A. Lubet, Ming You, Yukihiko Hara, Seto Ryota, Jun He, Yian Wang, Huijing Fu |
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| Rok vydání: | 2010 |
| Předmět: |
Pathology
medicine.medical_specialty Lung Neoplasms Ratón medicine.medical_treatment Intraperitoneal injection Pharmaceutical Science Polyphenon E Epigallocatechin gallate Pharmacology medicine.disease_cause Chemoprevention complex mixtures Catechin Article Mice chemistry.chemical_compound medicine Animals Anticarcinogenic Agents heterocyclic compounds Pharmacology (medical) Lung cancer Lung Chemotherapy business.industry Organic Chemistry food and beverages medicine.disease chemistry Molecular Medicine Female sense organs Carcinogenesis business Biotechnology |
| Zdroj: | Pharmaceutical Research. 27:1066-1071 |
| ISSN: | 1573-904X 0724-8741 |
| DOI: | 10.1007/s11095-010-0056-3 |
| Popis: | To compare the chemopreventive efficacy of Polyphenon E (Poly E), (−)-epigallocatechin-3-gallate (EGCG) and Polyphenon E without EGCG (Poly E-EGCG) on the development of benzo(a)pyrene (B(a)P)-induced lung tumors in A/J mice. Female A/J mice were given a single intraperitoneal injection of B(a)P (100 mg/kg body weight). One week after B(a)P injection, animals received AIN-76A purified powder diet containing 0.975% (wt/wt) EGCG, 0.525% (wt/wt) Poly E-EGCG or 1.5% (wt/wt) Poly E for 24 weeks or control diet with no additives. Poly E treatment significantly decreased tumor multiplicity by 52% and tumor load by 64%, while EGCG and Poly E-EGCG did not significantly inhibit lung tumor multiplicity. EGCG was more stable in a complex mixture (Poly E) than as a pure compound. EGCG was ineffective when administered by diet likely due to its instability. Thus, EGCG’s efficacy on mice lung tumorigenesis requires the presence of other tea catechins. |
| Databáze: | OpenAIRE |
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