Constituents of Huberantha jenkinsii and Their Biological Activities
| Autor: | Kittisak Likhitwitayawuid, Waraporn Putalun, Wanwimon Mekboonsonglarp, Hathairat Buraphaka, Htoo Tint San, Tanawat Chaowasku, Ratchanee Rodsiri, Boonchoo Sritularak |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Glucose uptake
Pharmaceutical Science Parkinsonism 01 natural sciences Analytical Chemistry lcsh:QD241-441 03 medical and health sciences chemistry.chemical_compound Allantoin lcsh:Organic chemistry Drug Discovery medicine Physical and Theoretical Chemistry Mangiferin 030304 developmental biology 0303 health sciences diabetes 010405 organic chemistry Huberantha jenkinsii Organic Chemistry Neurotoxicity Huberantha Tyramine medicine.disease 0104 chemical sciences glucose uptake chemistry Phytochemical Biochemistry Chemistry (miscellaneous) Molecular Medicine α-glucosidase Lead compound |
| Zdroj: | Molecules, Vol 25, Iss 3533, p 3533 (2020) Molecules Volume 25 Issue 15 |
| ISSN: | 1420-3049 |
| Popis: | The phytochemical investigation of Huberantha jenkinsii resulted in the isolation of two new and five known compounds. The new compounds were characterized as undescribed 8-oxoprotoberberine alkaloids and named huberanthines A and B, whereas the known compounds were identified as allantoin, oxylopinine, N-trans-feruloyl tyramine, N-trans-p-coumaroyl tyramine, and mangiferin. The structure determination was accomplished by spectroscopic methods. To evaluate therapeutic potential in diabetes and Parkinson&rsquo s disease, the isolates were subjected to assays for their &alpha glucosidase inhibitory activity, cellular glucose uptake stimulatory activity, and protective activity against neurotoxicity induced by 6-hydroxydopamine (6-OHDA). The results suggested that mangiferin was the most promising lead compound, demonstrating significant activity in all the test systems. |
| Databáze: | OpenAIRE |
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