Nuclear Localization of Heme Oxygenase-1 in Pathophysiological Conditions: Does It Explain the Dual Role in Cancer?
| Autor: | Maria Marta Facchinetti, Eliana Noelia Alonso, Alejandro Carlos Curino, Marilina Mascaró, Ezequiel Lacunza, Exequiel Alonso |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Proteases Physiology Medicina Clinical Biochemistry Smooth endoplasmic reticulum membrane Review Biochemistry 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine nuclear protein cancer oxidative stress Nuclear protein nuclear localization Molecular Biology Heme Biliverdin lcsh:RM1-950 nucleus heme oxygenase-1 Cell Biology Cell biology Heme oxygenase 030104 developmental biology lcsh:Therapeutics. Pharmacology chemistry 030220 oncology & carcinogenesis Signal peptide peptidase Nuclear localization sequence |
| Zdroj: | Antioxidants Antioxidants, Vol 10, Iss 87, p 87 (2021) SEDICI (UNLP) Universidad Nacional de La Plata instacron:UNLP |
| ISSN: | 2076-3921 |
| Popis: | Heme Oxygenase-1 (HO-1) is a type II detoxifying enzyme that catalyzes the rate-limiting step in heme degradation leading to the formation of equimolar quantities of carbon monoxide (CO), free iron and biliverdin. HO-1 was originally shown to localize at the smooth endoplasmic reticulum membrane (sER), although increasing evidence demonstrates that the protein translocates to other subcellular compartments including the nucleus. The nuclear translocation occurs after proteolytic cleavage by proteases including signal peptide peptidase and some cysteine proteases. In addition, nuclear translocation has been demonstrated to be involved in several cellular processes leading to cancer progression, including induction of resistance to therapy and enhanced metastatic activity. In this review, we focus on nuclear HO-1 implication in pathophysiological conditions with special emphasis on malignant processes. We provide a brief background on the current understanding of the mechanisms underlying how HO-1 leaves the sER membrane and migrates to the nucleus, the circumstances under which it does so and, maybe the most important and unknown aspect, what the function of HO-1 in the nucleus is. Facultad de Ciencias Médicas Centro de Investigaciones Inmunológicas Básicas y Aplicadas |
| Databáze: | OpenAIRE |
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