Radiosensitization of two murine fibrosarcomas with 6-thioguanine
| Autor: | Seung S. Hong, Sang Hie Kim, Alan A. Alfieri, Jae Ho Kim |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Male
Radiation-Sensitizing Agents Cancer Research Neoplasms Radiation-Induced Fibrosarcoma medicine.medical_treatment Mice chemistry.chemical_compound Pharmacokinetics In vivo Radioresistance Animals Medicine Radiology Nuclear Medicine and imaging Thioguanine Dose Modification Mice Inbred BALB C Mice Inbred C3H Radiation business.industry Therapeutic effect Dose-Response Relationship Radiation medicine.disease Combined Modality Therapy Radiation therapy Oncology chemistry Immunology Methylcholanthrene Cancer research business Neoplasm Transplantation |
| Zdroj: | International Journal of Radiation Oncology*Biology*Physics. 18:583-586 |
| ISSN: | 0360-3016 |
| DOI: | 10.1016/0360-3016(90)90064-q |
| Popis: | in vivo murine tumor experiments were carried out to determine whether 6-thioguanine (6-TG) could enhance the cytotoxic effects of radiation on tumors. The combined effects of single and fractionated x-irradiation were evaluated on the transplanted methylcholanthrene induced fibrosarcoma (Meth-A) in BALB/c mice, a moderately radio-responsive tumor and on the radiation induced fibrosarcoma (RIF) in C3H/He mice, a highly radioresistant tumor. The combined treatment of single administration of 6-TG (25 mg/kg) and of x-irradiation (20 Gy) on Meth-A tummor produced more than 90% tumor control, whereas the radiation alone resulted in less than 5% tumor control. The radiosensitizing effect by 6-TG was higher when the drug was administered either I to 8 hr prior to or 24 hr after x-irradiation. The dose modification factor of single dose 6-TG (10 mg/kg) is estimated to be 1.47 for Meth-A tumor and 1.25 for RIF tumor. The tumor control rates of fractionated irradiation alone and with concomitant 6-TG in Meth-A tumors were 14% and 59%, respectively. Based on the studies reported here and well documented pharmacokinetics in humans, it is suggested that combined radiation therapy and 6-TG may provide an enhanced therapeutic effect even in tumor varieties where the drug has no apparent anti-tumor activity on non-irradiated cells. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|