Characterizing prostatic adenocarcinomas in men with a serum prostate specific antigen level of <4.0 ng/mL
| Autor: | Charles B. Brendler, Mitchell H. Sokoloff, Michael J. Fumo, D. Mhoon, Ximing J. Yang |
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| Rok vydání: | 2004 |
| Předmět: |
Adult
Male Biochemical recurrence medicine.medical_specialty Pathology Urology Pathological staging medicine.medical_treatment Adenocarcinoma urologic and male genital diseases Prostate cancer Prostate Humans Medicine Aged PSA Velocity medicine.diagnostic_test business.industry Prostatectomy Prostatic Neoplasms Rectal examination Middle Aged Prostate-Specific Antigen medicine.disease Immunohistochemistry Prostate-specific antigen medicine.anatomical_structure business |
| Zdroj: | BJU International. 93:499-502 |
| ISSN: | 1464-410X 1464-4096 |
| Popis: | OBJECTIVE To characterize prostate cancer in men undergoing radical prostatectomy who have a prostate-specific antigen (PSA) level of 0.75 ng/mL/year (12%), a strong family history of prostate cancer (3%), obstructive urinary symptoms (2%), or no obvious indication (23%). Thirty-eight (48%) tumours were clinically insignificant. Of 41 clinically significant cancers, 13 had a final Gleason score of ≥ 7, 20 had extraprostatic extension and 11 had a tumour volume of ≥ 10 mL. Of the 79 prostate cancer specimens 78 stained strongly for PSA; the exception was a Gleason 9 tumour. With a mean (range) follow-up of 3.5 (0.18–6) years only one patient had a biochemical recurrence (PSA ≥ 0.1 ng/mL). CONCLUSIONS Most prostate cancers in men with a PSA level of |
| Databáze: | OpenAIRE |
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