Infections in Children With Cancer: The Role of the Presence or Absence of Neutropenia
| Autor: | Sophia Polychronopoulou, Lydia Kossiva, Kyriaki Karavanaki, Kostas Kakleas, Rigina Sklavou, Maria Tsolia, Dimitris Gourgiotis, Charalambos Tsentidis, Triantafyllia Sdogou, Antonis Marmarinos |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Neutropenia Fever Mucocutaneous zone medicine.disease_cause Gastroenterology 03 medical and health sciences 0302 clinical medicine 030225 pediatrics Internal medicine Neoplasms medicine Humans Fever of unknown origin Child medicine.diagnostic_test business.industry Antibody titer Complete blood count Cancer 030208 emergency & critical care medicine General Medicine Odds ratio medicine.disease Anti-Bacterial Agents Herpes simplex virus C-Reactive Protein Child Preschool Hematologic Neoplasms Pediatrics Perinatology and Child Health Emergency Medicine business |
| Zdroj: | Pediatric emergency care. 37(3) |
| ISSN: | 1535-1815 |
| Popis: | Background Infections in patients with cancer are a major cause of morbidity and mortality. In most cases, the presence of neutropenia renders them prone to infections to either common or opportunistic pathogens. A wide spectrum of bacterial, viral, or fungal agents is encountered in these patients. Aim The aim of this study was to evaluate infection types and pathogens in pediatric patients with cancer with and without neutropenia. Methods A total of 37 pediatric patients with cancer (median age ± 25% quartile, 6.0 ± 2.0% years) with 70 febrile episodes were evaluated at fever's onset and 48 hours later with complete blood count, C-reactive protein, cultures of biological fluids, polymerase chain reaction, and antibody titers. Results Of 70 infections, 30 (42.85%) were bacterial, 13 (18.57%) were viral, 3 (4.28%) were fungal, 16 (22.85%) were fever of unknown origin, 18 (25.71%) were opportunistic, and 12 (17.14%) were mixed infections. Neutropenia was detected in 42 (60.0%) of 70 febrile episodes, mainly in patients with hematological malignancies [odds ratio, 2.81 (0.96-8.22); P = 0.059]. Neutropenic patients had higher prevalence of mucocutaneous infections (47.6% vs 7.14%; P = 0.004). Herpes simplex virus 1 infections occurred only in the neutropenic group (14.3%). Conclusions Patients with cancer exhibited a high prevalence of bacterial (42.85%), opportunistic (25.7%), and mixed infections (17.14%). Patients with hematological malignancies and neutropenia presented higher frequency of mucocutaneous and herpes simplex virus 1 infections than the nonneutropenic ones. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|