Interleukin-13 is overexpressed in cutaneous T-cell lymphoma cells and regulates their proliferation
| Autor: | Larisa J. Geskin, Patrizia Fuschiotti, Sara Viragova, Donna B. Stolz |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Adult
Male Skin Neoplasms medicine.medical_treatment Immunology Biochemistry Young Adult Immune system hemic and lymphatic diseases Biomarkers Tumor medicine Sezary Syndrome Humans Autocrine signalling Receptor Aged Cell Proliferation Aged 80 and over Lymphoid Neoplasia Interleukin-13 Cell growth business.industry Cutaneous T-cell lymphoma Cell Biology Hematology Middle Aged medicine.disease Lymphoma T-Cell Cutaneous Cytokine Case-Control Studies Interleukin 13 Female Signal transduction business Signal Transduction |
| Zdroj: | Blood. 125:2798-2805 |
| ISSN: | 1528-0020 0006-4971 |
| Popis: | Cutaneous T-cell lymphomas (CTCLs) primarily affect skin and are characterized by proliferation of mature CD4(+) T-helper cells. The pattern of cytokine production in the skin and blood is considered to be of major importance for the pathogenesis of CTCLs. Abnormal cytokine expression in CTCLs may be responsible for enhanced proliferation of the malignant cells and/or depression of the antitumor immune response. Here we show that interleukin-13 (IL-13) and its receptors IL-13Rα1 and IL-13Rα2 are highly expressed in the clinically involved skin of CTCL patients. We also show that malignant lymphoma cells, identified by the coexpression of CD4 and TOX (thymus high-mobility group box), in the skin and blood of CTCL patients produce IL-13 and express both receptors. IL-13 induces CTCL cell growth in vitro and signaling through the IL-13Rα1. Furthermore, antibody-mediated neutralization of IL-13 or soluble IL-13Rα2 molecules can lead to inhibition of tumor-cell proliferation, implicating IL-13 as an autocrine factor in CTCL. Importantly, we established that IL-13 synergizes with IL-4 in inhibiting CTCL cell growth and that blocking the IL-4/IL-13 signaling pathway completely reverses tumor-cell proliferation. We conclude that IL-13 and its signaling mediators are novel markers of CTCL malignancy and potential therapeutic targets for intervention. |
| Databáze: | OpenAIRE |
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