Cytokeratins 18 and 8 are poor prognostic markers in patients with squamous cell carcinoma of the oesophagus
| Autor: | Shuji Takiguchi, Mitsuhiro Shirakawa, Kiyokazu Nakajima, Toshirou Nishida, Masaki Mori, Hiroshi Miyata, Yuichiro Doki, Noriko Matsuura, Makoto Yamasaki, Yoshiyuki Fujiwara, Tomoki Makino, Atsushi Takeno |
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| Rok vydání: | 2009 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty Pathology Esophageal Neoplasms Biopsy cytokeratin18 (CK18) Biology Cytokeratin quantitative reverse transcription polymerase chain reaction (RT–PCR) Biomarkers Tumor medicine Carcinoma Humans Basal cell carcinoma cytokeratin8 (CK8) Survival rate Aged Aged 80 and over Keratin-18 medicine.diagnostic_test Keratin-8 oesophageal squamous cell carcinoma (OSCC) Cancer Anatomical pathology Middle Aged Prognosis medicine.disease Immunohistochemistry immunohistochemistry (IHC) Survival Rate Oncology Epidermoid carcinoma Carcinoma Squamous Cell Female Translational Therapeutics |
| Zdroj: | British Journal of Cancer |
| ISSN: | 1532-1827 0007-0920 |
| DOI: | 10.1038/sj.bjc.6605313 |
| Popis: | Background: Cytokeratins (CKs) are structural marker proteins specific for epithelial cells. However, recent studies indicate their involvement in cancer progression. Methods: We evaluated CK18 and its filament partner, CK8 expression, by immunohistochemistry in 210 resected specimens from patients with oesophageal squamous cell carcinoma (OSCC). We also analysed the relationship between their expression and various clinicopathological parameters including prognosis. Results: Neither CK18 nor CK8 was expressed in non-cancerous squamous epithelium whereas proper oesophageal glands expressed both CKs. Ninety (42.9%) tumours were CK18 positive and 85 (40.5%) CK8 positive, and the concordance rate for immunohistochemical classification for CK18 and CK8 was 82.4%. CK18 expression correlated with poorly differentiated tumours, use of neo-adjuvant chemotherapy, and advanced stage. Prognosis of patients with CK18-positive tumours was poorer than that of patients with negative OSCC (P |
| Databáze: | OpenAIRE |
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