Comparison of intralesional corticosteroid and propranolol treatment of periorbital infantile hemangiomas: an outcome study of 61 cases
| Autor: | Chantal M.A.M. van der Horst, J. Joris Hage, Michael W.T. Tanck, Peerooz Saeed, Marije J. Hoornweg, Adriaan D. Coumou |
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| Přispěvatelé: | Other departments, CCA -Cancer Center Amsterdam, Other Research, Ophthalmology, APH - Amsterdam Public Health, Epidemiology and Data Science, ACS - Amsterdam Cardiovascular Sciences, Plastic, Reconstructive and Hand Surgery |
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Male
medicine.medical_specialty Skin Neoplasms Visual acuity End of therapy Prednisolone Adrenergic beta-Antagonists Visual Acuity Administration Oral Propranolol Injections Intralesional Eyelid Neoplasms Oral prednisolone Intralesional corticosteroid Interquartile range Infantile hemangioma medicine Humans Child Glucocorticoids business.industry Infant General Medicine Cheek Surgery Ophthalmology Treatment Outcome medicine.anatomical_structure Child Preschool Anesthesia Female medicine.symptom Hemangioma business medicine.drug |
| Zdroj: | European journal of ophthalmology, 24(6), 940-947. Wichtig Publishing |
| ISSN: | 1120-6721 |
| DOI: | 10.5301/ejo.5000467 |
| Popis: | Purpose To compare intralesional corticosteroid (IC) injections with oral propranolol in children with periorbital infantile hemangioma (IH). Methods Children were diagnosed with IH and treated with IC (n = 29) or propranolol (n = 14). In cases in which no further improvement was seen, treatment was stopped and the outcome measured. Type, duration, and complications of treatment and supportive or additional therapies were scored, along with outcomes of visual measurements, at the start and end of therapy. Results Twenty-one of the 29 children (72%) treated with IC injections were given a second injection and 16 (55%) were given more than two. Median duration of IC therapy was 15.9 months (interquartile range (IQR) 10.28), compared with 6.5 months (IQR 4.87) for propranolol (pConclusions The IC injections and oral propranolol medication equally improved amblyopia in children with IH of the periorbital and cheek region; however, propranolol was associated with fewer complications and additional or supportive treatment was not indicated. We prefer oral propranolol medication over IC injections in cases in which IH threatens to hamper visual acuity. |
| Databáze: | OpenAIRE |
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