Glycoprotein patterns in normal and malignant cervical tissue
| Autor: | B.E. Souberbielle, G.R.P. Blackledge, M.E.R. O'Brien, D.M. Luesley, G.R.B. Skinner, J. J. Mould, M.E. Cowan, C.A. Allen |
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| Rok vydání: | 1991 |
| Předmět: |
Adult
Cancer Research Biopsy Blotting Western Uterine Cervical Neoplasms Mannose Adenocarcinoma Fucose chemistry.chemical_compound Glycolipid Glucosamine Lectins Concanavalin A Tumor Cells Cultured Humans Aged Glycoproteins chemistry.chemical_classification Gel electrophoresis Chromatography biology Middle Aged Molecular biology Oncology chemistry Carcinoma Squamous Cell biology.protein Electrophoresis Polyacrylamide Gel Female Tumor-associated glycoprotein 72 Glycoprotein |
| Zdroj: | Cancer Letters. 58:247-254 |
| ISSN: | 0304-3835 |
| Popis: | Glycoproteins from normal and malignant human cervix were studied using an organ culture system and compared by gel electrophoresis and autoradiography. Five glycoproteins of 178 kDa, 95 kDa, 93 kDa, 82 kDa and 38 kDa and 1 glycolipid (46 kDa) were detected more frequently in squamous carcinomas. Certain glycoproteins were shown to be oncofoetal and some had affinity for Concanavalin A (Con A). The 82 kDa glycoprotein was present in 16 17 squamous carcinomas but in only 1 13 normal cervices. This band represented a glycoprotein containing glucosamine, mannose, small quantities of methionine and no fucose. These preliminary results suggest that these glycoproteins and in particular the 82-kDa glycoprotein are worthy of further investigation and characterisation. |
| Databáze: | OpenAIRE |
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