Insights into dovetailing GTD and Cancers
| Autor: | Jayashree Vijaya Vaman, Arathi Rajan, Revathy Nadhan, Geetu Rose Varghese, Priya Srinivas, Nirmala C, Ratheeshkumar Thankappan, Sreelatha K. Hemalatha, Satheesh Kumar Sengodan, Amritha Krishna Bv, R.L. Neetha |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Gynecology medicine.medical_specialty business.industry Incidence Choriocarcinoma Hematology Prognosis Placental Tumors Bioinformatics medicine.disease 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Breast cancer Oncology Pregnancy Neoplasms 030220 oncology & carcinogenesis medicine Humans Female Gestational Trophoblastic Disease business |
| Zdroj: | Critical Reviews in Oncology/Hematology. 114:77-90 |
| ISSN: | 1040-8428 |
| DOI: | 10.1016/j.critrevonc.2017.04.001 |
| Popis: | Gestational trophoblastic diseases (GTD) encompass a group of placental tumors which mostly arise due to certain fertilization defects, resulting in the over-proliferation of trophoblasts. The major characteristic of this diseased state is that β-hCG rises up manifold than that is observed during pregnancy. The incidence of GTD when analyzed on a global scale, figures out that there is a greater risk in South-East Asia, the reason of which remains unclear. An insight into any possible correlation of GTD incidence with cancers, other than choriocarcinoma, is being attempted here. Also, we review the recent developments in research on the molecular etiopathology of GTD. This review would render a wider eye towards a new paradigm of thoughts to connect GTD and breast cancer, which has not been into the picture till date. |
| Databáze: | OpenAIRE |
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