Tumor-educated mesenchymal stem cells promote pro-metastatic phenotype
| Autor: | Alessandra Pelagalli, Billy Samuel Hill, Antonella Zannetti, Nunzia Passaro |
|---|---|
| Přispěvatelé: | Hill Billy, Samuel, Pelagalli, Alessandra, Passaro, Nunzia, Zannetti, Antonella |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
mesenchymal stem cells Tumor microenvironment business.industry Mesenchymal stem cell epithelial-mesenchymal transition Clinical uses of mesenchymal stem cells Review mesenchymal stem cells CXCR4 3. Good health 03 medical and health sciences 030104 developmental biology Circulating tumor cell Oncology Tumor progression metastatic phenotype Cancer research tumor microenvironment Medicine Epithelial–mesenchymal transition Stem cell business Stem cell transplantation for articular cartilage repair |
| Zdroj: | Oncotarget Oncotarget 8 (2017): 73296–73311. doi:10.18632/oncotarget.20265 info:cnr-pdr/source/autori:Hill, Billy Samuel; Pelagalli, Alessandra; Passaro, Nunzia; Zannetti, Antonella/titolo:Tumor-educated mesenchymal stem cells promote pro-metastatic phenotype/doi:10.18632%2Foncotarget.20265/rivista:Oncotarget/anno:2017/pagina_da:73296/pagina_a:73311/intervallo_pagine:73296–73311/volume:8 Scopus-Elsevier |
| ISSN: | 1949-2553 |
| DOI: | 10.18632/oncotarget.20265 |
| Popis: | // Billy Samuel Hill 1, * , Alessandra Pelagalli 1, 2, * , Nunzia Passaro 1 and Antonella Zannetti 1 1 Institute of Biostructures and Bioimaging (IBB), National Research Council (CNR), Naples, Italy 2 Department of Advanced Biomedical Sciences, University of Naples “Federico II”, Naples, Italy * Authors contributed equally to this work Correspondence to: Antonella Zannetti, email: antonella.zannetti@cnr.it Keywords: mesenchymal stem cells, tumor microenvironment, epithelial-mesenchymal transition, metastatic phenotype Received: February 03, 2017 Accepted: August 04, 2017 Published: August 14, 2017 ABSTRACT Multipotent mesenchymal stem cells (MSCs) are recruited into tumor microenvironment in response to multiple signals produced by cancer cells. Molecules involved in their homing to tumors are the same inflammatory mediators produced by injured tissues: chemokines, cytokines and growth factors. When MSCs arrive into the tumor microenvironment these are “educated” to have pro-metastatic behaviour. Firstly, they promote cancer immunosuppression modulating both innate and adaptive immune systems. Moreover, tumor associated-MSCs trans-differentiating into cancer-associated fibroblasts can induce epithelial-mesenchymal-transition program in tumor cells. This process determinates a more aggressive phenotype of cancer cells by increasing their motility and invasiveness and favoring their dissemination to distant sites. In addition, MSCs are involved in the formation and modelling of pre-metastatic niches creating a supportive environment for colonization of circulating tumor cells. The development of novel therapeutic approaches targeting the different functions of MSCs in promoting tumor progression as well as the mechanisms underlying their activities could enhance the efficacy of conventional and immune anti-cancer therapies. Furthermore, many studies report the use of MSCs engineered to express different genes or as vehicle to specifically deliver novel drugs to tumors exploiting their strong tropism. Importantly, this approach can enhance local therapeutic efficacy and reduce the risk of systemic side effects. |
| Databáze: | OpenAIRE |
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