Role of soluble triggering receptor expressed in myeloid cells-1 in distinguishing SIRS, sepsis, and septic shock in the pediatric intensive care unit

Autor: Osman Yeşilbaş, Nermin Ankay, Burcu Bursal Duramaz, Hasan Serdar Kıhtır, Mey Talip Petmezci, Can Yilmaz Yozgat, Esra Şevketoğlu, Asuman Gedikbasi
Rok vydání: 2021
Předmět:
Male
medicine.medical_specialty
Myeloid
Adolescent
Intensive Care Units
Pediatric
Gastroenterology
Statistics
Nonparametric
Procalcitonin
Diagnosis
Differential
Sepsis
Internal medicine
White blood cell
medicine
Humans
Prospective Studies
Child
Pediatric intensive care unit
Chi-Square Distribution
Septic shock
business.industry
Organ dysfunction
Infant
Newborn
Infant
medicine.disease
Systemic Inflammatory Response Syndrome
Triggering Receptor Expressed on Myeloid Cells-1
Systemic inflammatory response syndrome
medicine.anatomical_structure
Child
Preschool
Pediatrics
Perinatology and Child Health
Female
Duramaz B. B.
Ankay N.
YEŞİLBAŞ O.
Kihtir H. S.
Yozgat C. Y.
Petmezci M. T.
Gedikbasi A.
Sevketoglu E.
-Role of soluble triggering receptor expressed in myeloid cells-1 in distinguishing SIRS
sepsis
and septic shock in the pediatric intensive care unit-
ARCHIVES DE PEDIATRIE
cilt.28
sa.7
ss.567-572
2021
medicine.symptom
business
Zdroj: Archives de Pédiatrie. 28:567-572
ISSN: 0929-693X
DOI: 10.1016/j.arcped.2021.06.001
Popis: Background Research into new markers has been intensified for early diagnosis, prognosis, and differentiation of SIRS, sepsis, and septic shock in recent years. This study aimed to investigate the role of soluble triggering receptor expressed in myeloid cells-1 (sTREM-1) and interleukin (IL)-6 in distinguishing between systemic inflammatory response syndrome (SIRS), sepsis, and septic shock in pediatric intensive care unit (PICU) patients. Methods Between June 2014 and July 2015, 90 consecutive patients who were treated in the PICU were included in this prospective observational study. Patients were divided into four groups: control (n = 23), SIRS (n = 22), sepsis (n = 23), and septic shock (n = 22). All patients were evaluated for white blood cell (WBC), serum C-reactive protein (CRP), procalcitonin (PCT), IL-6, and sTREM-1 levels at 0, 24, and 72 h of admission. The prognostic evaluations were made using the Pediatric Risk of Mortality III (PRISM III) and Pediatric Logistic Organ Dysfunction (PELOD) scores. Patients were evaluated in terms of age, gender, prognosis, pathogen growth in culture, PRISM III and PELOD score, WBC, CRP, PCT, IL-6, and sTREM-1 levels and a comparison was made between groups. Results There was no significant difference between all groups in terms of the 0-, 24-, and 72-h sTREM-1 values (p = 0.761, p = 0.360, and p = 0.822, respectively). CRP and PCT values did not differ between the septic shock, sepsis, and SIRS groups at 0, 24, and 72 h. In the septic shock group, the 0-h IL-6 value was significantly higher than that of the SIRS group (p = 0.025). The 24-h IL-6 value in the septic shock group was significantly higher than the values of the sepsis and SIRS groups (p = 0.048 and p = 0.043, respectively). No significant difference was detected between the septic shock, sepsis, and SIRS groups in terms of IL-6 values at 72 h. Conclusion sTREM-1 is not useful for the diagnosis of infection and for distinguishing between sepsis, septic shock, and SIRS since it does not offer a clear diagnostic value for PICU patients, unlike other reliable markers such as WBC, CRP, and PCT. Elevated IL-6 levels may indicate septic shock in PICU patients. More research on sTREM-1 is needed in this setting.
Databáze: OpenAIRE
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