Imaging coronary plaques using 3D motion-compensated [18F]NaF PET/MR

Autor:	Winfried Brenner, Marcus R. Makowski, Bernd Hamm, Thomas-Heinrich Wurster, Ulf Landmesser, Tobias Schaeffter, Christoph Kolbitsch, Boris Bigalke, Johannes Mayer, Andreas J. Morguet
Rok vydání:	2021
Předmět:	Materials science Image quality Simultaneous PET/MR [18F]NaF cardiac imaging Motion (geometry) 030204 cardiovascular system & hematology Multimodal Imaging 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Cardiac motion Image Processing Computer-Assisted simultaneous PET/MR Humans Radiology Nuclear Medicine and imaging Physiological motion Retrospective Studies Motion compensation Attenuation Heart General Medicine Magnetic Resonance Imaging ddc motion compensation cardiac and respiratory motion Atherosclerosis Cardiac PET Positron-Emission Tomography Original Article atherosclerosis Artifacts Correction for attenuation 600 Technik Medizin angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit Biomedical engineering
Zdroj:	European Journal of Nuclear Medicine and Molecular Imaging
ISSN:	1619-7089 1619-7070
DOI:	10.1007/s00259-020-05180-4
Popis:	Background Cardiac PET has recently found novel applications in coronary atherosclerosis imaging using [18F]NaF as a radiotracer, highlighting vulnerable plaques. However, the resulting uptakes are relatively small, and cardiac motion and respiration-induced movement of the heart can impair the reconstructed images due to motion blurring and attenuation correction mismatches. This study aimed to apply an MR-based motion compensation framework to [18F]NaF data yielding high-resolution motion-compensated PET and MR images. Methods Free-breathing 3-dimensional Dixon MR data were acquired, retrospectively binned into multiple respiratory and cardiac motion states, and split into fat and water fraction using a model-based reconstruction framework. From the dynamic MR reconstructions, both a non-rigid cardiorespiratory motion model and a motion-resolved attenuation map were generated and applied to the PET data to improve image quality. The approach was tested in 10 patients and focal tracer hotspots were evaluated concerning their target-to-background ratio, contrast-to-background ratio, and their diameter. Results MR-based motion models were successfully applied to compensate for physiological motion in both PET and MR. Target-to-background ratios of identified plaques improved by 7 ± 7%, contrast-to-background ratios by 26 ± 38%, and the plaque diameter decreased by −22 ± 18%. MR-based dynamic attenuation correction strongly reduced attenuation correction artefacts and was not affected by stent-related signal voids in the underlying MR reconstructions. Conclusions The MR-based motion correction framework presented here can improve the target-to-background, contrast-to-background, and width of focal tracer hotspots in the coronary system. The dynamic attenuation correction could effectively mitigate the risk of attenuation correction artefacts in the coronaries at the lung-soft tissue boundary. In combination, this could enable a more reproducible and reliable plaque localisation.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9c3d7191772bf4bf66aa09bdd0a56c7 https://doi.org/10.1007/s00259-020-05180-4 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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