Aspidosperma pyrifolium Mart: neuroprotective, antioxidant and anti-inflammatory effects in a Parkinson's disease model in rats
| Autor: | Glauce Socorro de Barros Viana, Edilberto R. Silveira, Roberta de Oliveira Costa, Luzia Kalyne Almeida Moreira Leal, Alan Diego da Conceição Santos, Kelly Rose Tavares Neves, Patrícia Coelho do Nascimento Nogueira, Jalles Dantas de Lucena, Dayane Pessoa de Araújo, Carlos Vinicius Jataí Gadelha-Filho, Francisco Arnaldo Viana Lima |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Aspidosperma Male Antioxidant Tyrosine 3-Monooxygenase medicine.medical_treatment Dopamine Anti-Inflammatory Agents Pharmaceutical Science Pharmacology Neuroprotection Antioxidants Lipid peroxidation 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Neurochemical medicine Animals Oxidopamine Nitrites Dopamine transporter Dopamine Plasma Membrane Transport Proteins Tyrosine hydroxylase biology Behavior Animal Plant Extracts Tumor Necrosis Factor-alpha Parkinson Disease biology.organism_classification Corpus Striatum Rats Disease Models Animal 030104 developmental biology Neuroprotective Agents chemistry Seeds biology.protein Lipid Peroxidation 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | The Journal of pharmacy and pharmacology. 70(6) |
| ISSN: | 2042-7158 |
| Popis: | Objectives Aspidosperma species are used for several diseases, especially for malaria in Brazil. Although the genus is object of pharmacological studies, almost none are found on Aspidosperma pyrifolium. We investigate neuroprotective, antioxidant and anti-inflammatory properties of the APSE-Aq fraction (benzoic acid glycosylated derivative) on Parkinson's disease model. Methods Male Wistar rats were subjected to a 6-hydroxydopamine injection into the right striatum and treated or not with APSE-Aq (100 or 200 mg/kg, p.o.). The sham-operated group was injected with saline. Two weeks later, animals were subjected to behavioural, neurochemical and immunohistochemical evaluation. The data were analysed by ANOVA and Tukey test. Key findings The APSE-Aq-treated group shows a partial recovery of behavioural changes as compared with the untreated-6-hydroxydopamine group. A partial recovery was also observed in nitrite contents and lipid peroxidation. APSE-Aq treatments significantly reversed decreases in striatal dopamine and metabolites in the untreated 6-hydroxydopamine group. Immunostainings for markers as tyrosine hydroxylase and dopamine transporter decreased in the untreated 6-hydroxydopamine group and values recovered after APSE-Aq treatments. Similar data were seen for TNF-alpha. Conclusion APSE-Aq presents neuroprotective, antioxidant and anti-inflammatory activities. Considering that APSE-Aq is chemically related to salicylic acid, it may act on similar targets. |
| Databáze: | OpenAIRE |
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