The evolving landscape for cellular nitric oxide and hydrogen sulfide delivery systems: A new era of customized medications
| Autor: | Kearsley M. Dillon, Ryan J. Carrazzone, John B. Matson, Khosrow Kashfi |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Hydrogen sulfide Cystathionine beta-Synthase Nanotechnology Nitric Oxide Biochemistry Article Nitric oxide 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Animals Humans Cysteine Hydrogen Sulfide A fibers Gasotransmitters Pharmacology Cystathionine gamma-Lyase 030104 developmental biology chemistry 030220 oncology & carcinogenesis Self-healing hydrogels Nitric Oxide Synthase Signal Transduction |
| Zdroj: | Biochem Pharmacol |
| ISSN: | 0006-2952 |
| Popis: | Nitric oxide (NO) and hydrogen sulfide (H(2)S) are industrial toxins or pollutants; however, both are produced endogenously and have important biological roles in most mammalian tissues. The recognition that these gasotransmitters have a role in physiological and pathophysiological processes has presented opportunities to harness their intracellular effects either through inhibition of their production; or more commonly, through inducing their levels and or delivering them by various modalities. In this review article, we have focused on an array of NO and H(2)S donors, their hybrids with other established class of drugs, and the various engineered delivery platforms such a fibers, polymers, nanoparticles, hydrogels, and others. In each case, we have reviewed the rationale for their development. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect