High-yielding sequential one-pot synthesis of chiral and achiral α-substituted acrylates via a metal-free reductive coupling reaction

Autor:	Y. Vijayendar Reddy, Dhevalapally B. Ramachary, Chintalapudi Venkaiah
Rok vydání:	2014
Předmět:	chemistry.chemical_classification Organic Chemistry One-pot synthesis Salt (chemistry) Alcohol Biochemistry High yielding Coupling reaction Catalysis Solvent chemistry.chemical_compound chemistry Organic chemistry Physical and Theoretical Chemistry
Zdroj:	Org. Biomol. Chem.. 12:5400-5406
ISSN:	1477-0539 1477-0520
DOI:	10.1039/c4ob00667d
Popis:	A general process for the high-yielding synthesis of substituted chiral and achiral α-substituted acrylates was achieved through the sequential one-pot combination of a metal-free reductive coupling reaction followed by an Eschenmoser methylenation. The proline catalyzed reaction of Meldrum's acid, aldehydes and Hantzsch ester followed by methylenation was successful with Eschenmoser's salt in the presence of an alcohol solvent. Herein, we have shown the high-yielding synthesis of privileged building blocks from chiral/achiral α-substituted acrylates and shown them to be very good intermediates in the pharmaceuticals and natural products synthesis.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9c0d54b94e57c1af0d4d65482093811 https://doi.org/10.1039/c4ob00667d Zobrazit plný text záznamu