The comparative effects of Resveratrol and Curcumin in combination with photodynamic therapy
| Autor: | István-Péter, Laszló, Mihaela Ramona, Laszló, Tiberiu, Popescu, Vlad, Toma, Rodica Mariana, Ion, Remus, Moldovan, Gabriela Adriana, Filip, Calin, Cainap, Simona, Clichici, Adriana, Muresan |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Medicine and Pharmacy Reports. |
| ISSN: | 2668-0572 2602-0807 |
| DOI: | 10.15386/mpr-2497 |
| Popis: | Background and aim. Photodynamic therapy, PDT, is a promising option among the local treatments with oncolytic potential. Although the basic principle is simple, its intricate mechanisms allow for a broad range of optimization methods. The purpose of this study was to assess the effects of Resveratrol and Curcumin as adjuvants of PDT on experimental tumors. Methods. Sixty-six Wistar male rats were divided into 11 groups: control, Curcumin (CUR), Resveratrol (RES) alone or followed by irradiation (IR) (CUR+IR and RES+IR, respectively), 5,10,15,20-tetra-sulphonato-phenyl-porphyrin (TSPP), TSPP+IR (PDT), and CUR or RES administered prior to or after PDT (CUR+TSPP+IR, RES+TSPP+IR, TSPP+IR+CUR, TSPP+IR+RES). Results. Both CUR and RES significantly decreased lipid peroxidation, while RES also showed an increase in glutathione (GSH) levels, especially when it was administered before PDT (p |
| Databáze: | OpenAIRE |
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