Antibacterial activity and cytotoxicity of l‑phenylalanine-oxidized starch-coordinated zinc (II)
| Autor: | Minmin Chen, Junfeng Cheng, Linlin Li, Hualin Wang, Suwei Jiang, Chongyang Jin, Shaotong Jiang |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
food.ingredient
Phenylalanine chemistry.chemical_element 02 engineering and technology Zinc Microbial Sensitivity Tests Biochemistry Coordination complex 03 medical and health sciences symbols.namesake food Structural Biology Cell Line Tumor Escherichia coli Organic chemistry Humans Cytotoxicity Molecular Biology 030304 developmental biology chemistry.chemical_classification 0303 health sciences Reactive oxygen species Cytotoxins Food additive fungi Starch General Medicine 021001 nanoscience & nanotechnology Anti-Bacterial Agents Maillard reaction chemistry symbols 0210 nano-technology Antibacterial activity Reactive Oxygen Species HT29 Cells Bacillus subtilis |
| Zdroj: | International journal of biological macromolecules. 123 |
| ISSN: | 1879-0003 |
| Popis: | Zn (II) coordination compounds have aroused growing attentions as antibacterial entities. In the present work, we fabricated a new antibacterial complex of l‑phenylalanine‑oxidized starch-coordinated zinc (II) (l‑Phe-OSt→Zn (II)) by successive reactions of oxidization, Maillard and coordination. Maillard reaction occurred between l‑Phe and OSt to form l‑Phe-OSt, which was then coordinated with Zn (II) by carboxyl groups for l‑Phe-OSt→Zn (II). The complex showed good antibacterial activity and the antibacterial activity against E. coli was slightly poorer than B. subtilis. The presence of complex favored the generation of reactive oxygen species (ROS) in bacteria and the ROS level in B. subtilis was higher than that in E. coli. Furthermore, the toxicity of l‑Phe-OSt→Zn (II) towards HT-29 cells was very low. The characteristics of better antibacterial activity and less cytotoxicity endow l‑Phe-OSt→Zn (II) a great potential of application as a food additive. |
| Databáze: | OpenAIRE |
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