Microvascular Invasion Status and Its Survival Impact in Hepatocellular Carcinoma Depend on Tissue Sampling Protocol
| Autor: | Guanrui Liao, Luying Zhu, Dongming Li, Bin Li, Yu Dong, Shuling Chen, Li Tan, Han Xiao, Sui Peng, Bing Liao, Zhenwei Peng, Shi-Ting Feng, Ming Kuang, Lili Chen, Baogang Peng, Zunfu Ke, Xin Liu, Qian Zhou, Yuanqi Wang, Qinghua Cao |
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| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Carcinoma Hepatocellular medicine.medical_treatment Gastroenterology 03 medical and health sciences 0302 clinical medicine Surgical oncology Internal medicine Parenchyma Medicine Hepatectomy Humans Neoplasm Invasiveness Prospective Studies Multiple tumors Prospective cohort study Retrospective Studies business.industry Hazard ratio Liver Neoplasms Tissue sampling medicine.disease Oncology 030220 oncology & carcinogenesis Hepatocellular carcinoma Microvessels 030211 gastroenterology & hepatology Surgery Neoplasm Recurrence Local business |
| Zdroj: | Annals of surgical oncology. 28(11) |
| ISSN: | 1534-4681 |
| Popis: | The aim of this work is to explore the impact of the number of sampling sites (NuSS) and sampling location on microvascular invasion (MVI) detection rate and long-term survival of hepatocellular carcinoma (HCC), and determine the minimum NuSS for sufficient MVI detection. From January 2008 to March 2017, 1144 HCC patients who underwent hepatectomy were retrospectively enrolled. Associations between NuSS and MVI positive rates and overall survival were investigated. NuSS thresholds were determined by Chow test and confirmed prospectively in 305 patients from April 2017 to February 2019. In the prospective cohort, the distribution of MVI in different sampling locations and its prognostic effect was evaluated. MVI positive rates increased as NuSS increased, steadily reaching a plateau when NuSS reached a threshold. A threshold of four, six, eight, and eight sampling sites within paracancerous parenchyma ≤ 1 cm from tumor was required for detecting MVI in solitary tumors measuring 1.0–3.0, 3.1–4.9, and ≥ 5.0 cm and multiple tumors. Patients with adequate NuSS achieved longer survival than those with inadequate NuSS [hazard ratio (HR) = 0.75, P = 0.043]. For all MVI-positive patients, MVI could be detected positive in paracancerous parenchyma ≤ 1 cm from tumor. Patients with MVI positive in paracancerous parenchyma > 1 cm had higher recurrence risk than those with MVI positive only in parenchyma ≤ 1 cm (HR = 6.05, P |
| Databáze: | OpenAIRE |
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