Circulating insulin-like growth factor I modulates mood and is a biomarker of vulnerability to stress:from mouse to man
| Autor: | I. Torres Aleman, Brenda W.J.H. Penninx, André Aleman, Mariska Bot, Andrea Santi |
|---|---|
| Přispěvatelé: | Clinical Neuropsychology, Interdisciplinary Centre Psychopathology and Emotion regulation (ICPE), Perceptual and Cognitive Neuroscience (PCN), Clinical Cognitive Neuropsychiatry Research Program (CCNP), APH - Mental Health, Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep, Psychiatry, APH - Digital Health |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine DISORDER SERUM IGF1 medicine.medical_treatment Anxiety Dexamethasone Stress Disorders Post-Traumatic Mice Insulin-like growth factor 0302 clinical medicine Glucocorticoid receptor Homeostasis Insulin-Like Growth Factor I GENE-EXPRESSION education.field_of_study ASSOCIATION Middle Aged IGF-I Psychiatry and Mental health FKBP5 Female medicine.symptom Adult medicine.medical_specialty Traumatic brain injury Population TRAUMATIC BRAIN-INJURY PERIPHERAL-BLOOD Article lcsh:RC321-571 Tacrolimus Binding Proteins 03 medical and health sciences Cellular and Molecular Neuroscience HORMONE Internal medicine medicine Animals Humans Rats Wistar education lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry Biological Psychiatry business.industry medicine.disease Rats Mice Inbred C57BL Affect 030104 developmental biology Endocrinology Anxiogenic BRITISH BIRTH COHORT business Biomarkers Stress Psychological 030217 neurology & neurosurgery Hormone |
| Zdroj: | Santi, A, Bot, M, Aleman, A, Penninx, B W J H & Aleman, I T 2018, ' Circulating insulin-like growth factor I modulates mood and is a biomarker of vulnerability to stress : from mouse to man ', Translational Psychiatry, vol. 8, no. 1, 142 . https://doi.org/10.1038/s41398-018-0196-5 Translational Psychiatry, 8:142. Nature Publishing Group Translational Psychiatry Translational Psychiatry, 8(1):142. Nature Publishing Group Translational Psychiatry, Vol 8, Iss 1, Pp 1-11 (2018) |
| ISSN: | 2158-3188 |
| DOI: | 10.1038/s41398-018-0196-5 |
| Popis: | Individual susceptibility to anxiety disorders after maladaptive responses to stress is not well understood. We now report that while exploring stress responses in mice after traumatic brain injury (TBI), a condition associated to stress susceptibility, we observed that the anxiogenic effects of either TBI or exposure to life-threatening experiences (predator) were blocked when both stressors were combined. Because TBI increases the entrance into the brain of serum insulin-like growth factor I (IGF-I), a known modulator of anxiety with a wide range of concentrations in the human population, we then determined whether circulating IGF-I is related to anxiety measures. In mice, anxiety-like responses to predator were inversely related to circulating IGF-I levels. Other indicators of mood regulation such as sensitivity to dexamethasone suppression and expression levels of blood and brain FK506 binding protein 5 (FKBP5), a co-chaperone of the glucocorticoid receptor that regulates its activity, were also associated to circulating IGF-I. Indeed, brain FKBP5 expression in mice was stimulated by IGF-I. In addition, we observed in a large human cohort (n = 2686) a significant relationship between plasma IGF-I and exposure to recent stressful life events, while FKBP5 expression in blood cells was significantly associated to plasma IGF-I levels. Collectively, these data indicate that circulating IGF-I appears to be involved in mood homeostasis across different species. Furthermore, the data in mice allow us to indicate that IGF-I may be acting at least in part by modulating FKBP5 expression. |
| Databáze: | OpenAIRE |
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