Development, Validation and Testing of an Epidemiological Case Definition of Interstitial Cystitis/Painful Bladder Syndrome
| Autor: | Michael A. Stoto, Karin Liu, J. Quentin Clemens, Chau Pham, Marika J. Suttorp, Sandra H. Berry, Leroy M. Nyberg, Laura M. Bogart |
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| Rok vydání: | 2010 |
| Předmět: |
medicine.medical_specialty
Vulvodynia Urology Urinary system Cystitis Interstitial Endometriosis Pain urologic and male genital diseases Sensitivity and Specificity Article Diagnosis Differential Interviews as Topic Surveys and Questionnaires Prevalence medicine Humans Urinary bladder Urinary Bladder Overactive business.industry Urinary Bladder Diseases Interstitial cystitis Syndrome medicine.disease Dermatology United States Surgery medicine.anatomical_structure Overactive bladder Female Differential diagnosis business Urinary bladder disease |
| Zdroj: | Journal of Urology. 183:1848-1852 |
| ISSN: | 1527-3792 0022-5347 |
| Popis: | No standard case definition exists for interstitial cystitis/painful bladder syndrome for patient screening or epidemiological studies. As part of the RAND Interstitial Cystitis Epidemiology study, we developed a case definition for interstitial cystitis/painful bladder syndrome with known sensitivity and specificity. We compared this definition with others used in interstitial cystitis/painful bladder syndrome epidemiological studies.We reviewed the literature and performed a structured, expert panel process to arrive at an interstitial cystitis/painful bladder syndrome case definition. We developed a questionnaire to assess interstitial cystitis/painful bladder syndrome symptoms using this case definition and others used in the literature. We administered the questionnaire to 599 women with interstitial cystitis/painful bladder syndrome, overactive bladder, endometriosis or vulvodynia. The sensitivity and specificity of each definition was calculated using physician assigned diagnoses as the reference standard.No single epidemiological definition had high sensitivity and high specificity. Thus, 2 definitions were developed. One had high sensitivity (81%) and low specificity (54%), and the other had the converse (48% sensitivity and 83% specificity). These values were comparable or superior to those of other epidemiological definitions used in interstitial cystitis/painful bladder syndrome prevalence studies.No single case definition of interstitial cystitis/painful bladder syndrome provides high sensitivity and high specificity to identify the condition. For prevalence studies of interstitial cystitis/painful bladder syndrome the best approach may be to use 2 definitions that would yield a prevalence range. The RAND Interstitial Cystitis Epidemiology interstitial cystitis/painful bladder syndrome case definitions, developed through structured consensus and validation, can be used for this purpose. |
| Databáze: | OpenAIRE |
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