Eight week exposure to a high sugar high fat diet results in adiposity gain and alterations in metabolic biomarkers in baboons (Papio hamadryas sp.)

Autor: Robert E. Shade, M. Elizabeth Tejero, Paul B. Higgins, J. Michael Proffitt, Shelley A. Cole, Maggie Garcia-Forey, Anthony G. Comuzzie, Raul A. Bastarrachea, Vicki Mattern, Juan Carlos López-Alvarenga, V. Saroja Voruganti, Karin Haack
Jazyk: angličtina
Rok vydání: 2010
Předmět:
Leptin
Male
lcsh:Diseases of the circulatory (Cardiovascular) system
Time Factors
Endocrinology
Diabetes and Metabolism
chemistry.chemical_compound
0302 clinical medicine
Absorptiometry
Photon
Dietary Sucrose
Medicine
Insulin
Adiposity
Original Investigation
2. Zero hunger
Metabolic Syndrome
0303 health sciences
biology
3. Good health
C-Reactive Protein
Papio hamadryas
Adiponectin
Energy source
Cardiology and Cardiovascular Medicine
medicine.medical_specialty
Adipokine
030209 endocrinology & metabolism
03 medical and health sciences
biology.animal
Diabetes mellitus
Internal medicine
Animals
Obesity
Triglycerides
030304 developmental biology
Glycated Hemoglobin
Triglyceride
business.industry
medicine.disease
Dietary Fats
Endocrinology
chemistry
lcsh:RC666-701
business
Energy Intake
Energy Metabolism
Biomarkers
Baboon
Zdroj: Cardiovascular Diabetology, Vol 9, Iss 1, p 71 (2010)
Cardiovascular Diabetology
ISSN: 1475-2840
Popis: Background Baboons (Papio hamadryas Sp.) develop features of the cardiometabolic syndrome and represent a clinically-relevant animal model in which to study the aetiology of the disorder. To further evaluate the baboon as a model for the study of the cardiometabolic syndrome, we developed a high sugar high fat diet and hypothesized that it could be used to induce adiposity gain and affect associated circulating biomarkers. Methods We developed a diet enriched with monosaccharides and saturated fatty acids that was composed of solid and liquid energy sources. We provided a group of baboons (n = 9) ad libitum access to this diet for 8 weeks. Concurrently, a control group (n = 6) was maintained with ad libitum access to a low sugar low fat baseline diet and normal water for 8 weeks. Body composition was determined by dual-energy X-ray absorptiometry and circulating metabolic biomarkers were measured using standard methodology before and after the 8 week study period. Results Neither body composition nor circulating biomarkers changed in the control group. Following the 8 weeks, the intervention group had a significant increase in fat mass (1.71 ± 0.98 vs. 3.23 ± 1.70 kg, p = 0.004), triglyceride (55 ± 13 vs. 109 ± 67 mg/dL, p = 0.006,), and leptin (1.19 ± 1.40 vs. 3.29 ± 2.32 ng/mL, p = 0.001) and a decline in adiponectin concentrations (33530 ± 9744 vs. 23330 ± 7863 ng/mL, p = 0.002). Percentage haemoglobin A1C (4.0 ± 0.3 vs. 6.0 ± 1.4, p = 0.002) also increased in the intervention group. Conclusions Our findings indicate that when exposed to a high sugar high fat diet, young adult male baboons develop increased body fat and triglyceride concentrations, altered adipokine concentrations, and evidence of altered glucose metabolism. Our findings are in keeping with observations in humans and further demonstrate the potential utility of this highly clinically-relevant animal model for studying diet-induced metabolic dysregulation.
Databáze: OpenAIRE
Externí odkaz: