Short Communication: Immune Activation Is Present in HIV-1-Exposed Seronegative Individuals and Is Independent of Microbial Translocation
| Autor: | Mara Biasin, Daria Trabattoni, Federica Gnudi, Veronica Rainone, Irma Saulle, Salomè Valentina Ibba, Sergio Lo Caputo, Francesco Mazzotta, Mario Clerici |
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| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
Adult CD4-Positive T-Lymphocytes Lipopolysaccharides Male Lipopolysaccharide animal diseases Immunology chemical and pharmacologic phenomena HIV Infections Biology CD8-Positive T-Lymphocytes HIV Antibodies Lymphocyte Activation Virus 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Immune system Immunity Virology HIV Seronegativity Humans 030212 general & internal medicine Innate immune system T lymphocyte biochemical phenomena metabolism and nutrition Viral Load Phenotype Immunity Innate CD4 Lymphocyte Count 030104 developmental biology Infectious Diseases chemistry Italy HIV-1 bacteria Cytokines Female Viral load |
| Zdroj: | AIDS research and human retroviruses. 32(2) |
| ISSN: | 1931-8405 |
| Popis: | Analyses of immune activation in HIV-exposed seronegative individuals (HESN) yielded discrepant results. To clarify this issue we performed an extensive investigation of immune parameters in HESN and, in particular, we analyzed in these individuals the possible presence of microbial translocation, the most widely accepted reason driving immune activation in HIV-infected patients. Results showed that immune activation, a skewing of T lymphocyte maturation, and increased responsiveness to lipopolysaccharide (LPS) characterize the HESN phenotype; this is not driven by alterations of the gastrointestinal barrier and microbial translocation. The activation state seen in HESN may influence the induction of stronger adaptive antiviral immune responses and may represent a virus exposure-induced innate immune protective phenotype against HIV. |
| Databáze: | OpenAIRE |
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