Increased Levels ofCandida albicansMannan-Specific T-Cell-Derived Antigen Binding Molecules in Patients with Invasive Candidiasis
| Autor: | Pirjo-Riitta Harjamäki, Johannes Savolainen, George Georgiou, Colin H. Little, Jan Kosonen, Rantala A, Robert E. Cone, Päivi Lintu |
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| Rok vydání: | 2006 |
| Předmět: |
Adult
Male Microbiology (medical) Antigens Fungal Adolescent T cell Clinical Biochemistry Immunology Epitopes T-Lymphocyte Microbiology Mannans Interferon-gamma Immune system T-Lymphocyte Subsets Immunity Candida albicans medicine Humans Immunology and Allergy Interferon gamma RNA Messenger Aged Mannan Aged 80 and over biology Candidiasis Middle Aged biology.organism_classification medicine.anatomical_structure biology.protein Recurrent vulvovaginal candidiasis Female Interleukin-4 Microbial Immunology Antibody medicine.drug |
| Zdroj: | Clinical and Vaccine Immunology. 13:467-474 |
| ISSN: | 1556-679X 1556-6811 |
| Popis: | In addition to cytokines, CD4+T cells have been found to secrete soluble, T-cell-derived antigen binding molecules (TABMs). These antigen-specific immunoproteins are thought to have immunoregulatory properties in the suppression of cell-mediated immunity (CMI) because they often associate with interleukin-10 (IL-10) and transforming growth factor beta. Decreased CMI causes susceptibility to infections caused by organisms which are normally nonpathogenic. In this situation, e.g.,Candida albicanssaprophytism may develop into invasive candidiasis. The difficult diagnosis of invasive candidiasis is based on the findings obtained from blood cultures and with tissue biopsy specimens, with some additional diagnostic value gained by the detection ofCandida albicansmannan antigenemia and antimannan antibodies. In the present study,Candida albicansmannan-specific TABM (CAM-TABM) levels in the sera of patients with invasive candidiasis (n= 11),Candidacolonization (n= 11) and noncolonization (n= 10), recurrent vulvovaginal candidiasis (n= 30), and atopic eczema dermatitis syndrome (n= 59) and healthy controls (n= 30) were analyzed. For 14 participants, the effect of mannan stimulation on TABM production and gamma interferon (IFN-γ) and IL-4 mRNA expression by peripheral blood lymphocytes was also studied. It was demonstrated that CAM-TABM production was the highest in patients with invasive candidiasis and that CAM-TABM levels could distinguishCandida-colonized patients from noncolonized patients. In addition, the CAM-TABM level was directly related to mRNA expression for IL-4 but not IFN-γ. These results reinforce the view that TABMs are associated with decreased CMI, immunoregulation, and the T-helper cell 2-type immune response. |
| Databáze: | OpenAIRE |
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