Lanostane triterpenoids from cultivated fruiting bodies of Ganoderma sichuanense: Determination of the C-25 absolute configuration of ganoderic acid A and its derivatives using the phenylglycine methyl ester (PGME) method
| Autor: | Thitiya Boonpratuang, Pranee Rachtawee, Panida Chinthanom, Kitlada Srichomthong, Masahiko Isaka, Rattaket Choeyklin, Ji-Kai Liu, Tao Feng |
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| Rok vydání: | 2021 |
| Předmět: |
Stereochemistry
Glycine Plant Science Horticulture Biochemistry Lanostane chemistry.chemical_compound Lanosterol Ganoderma sichuanense Triterpenoid Fruiting Bodies Fungal Molecular Biology Taxonomy Ganodermataceae Phenylglycine methyl ester biology Molecular Structure Chemistry Absolute configuration Ganoderic acid Ganoderma General Medicine Biodiversity biology.organism_classification Triterpenes Heptanoic Acids Ganoderiol F |
| Zdroj: | Phytochemistry. 192 |
| ISSN: | 1873-3700 |
| Popis: | Three undescribed lanostane triterpenoids, together with twenty-one known compounds, were isolated from artificially cultivated fruiting bodies of the basidiomycete Ganoderma sichuanense. The absolute configuration at C-25 of ganoderic acid A and its derivatives was determined to be 25R by application of the phenylglycine methyl ester (PGME) method. Among the isolated compounds, ganoderiol F exhibited the most potent activity against Mycobacterium tuberculosis H37Ra with an MIC value of 0.781 μg/ml. |
| Databáze: | OpenAIRE |
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