Seasonal Human Coronavirus Respiratory Tract Infection in Recipients of Allogeneic Hematopoietic Stem Cell Transplantation

Autor: Tulay Ozcelik, Vanderson Rocha, Mohsen Al Zahrani, Amato Viviana, Rafael de la Cámara, Jakob Passweg, Nina Knelange, Aliénor Xhaard, María Suárez-Lledó, Musa Karakukcu, Maija Itälä-Remes, Arnold Ganser, José Luis Piñana, Baris Kuskonmaz, Isabel Iturrate Basarán, Dagmar Berghuis, Malgorzata Mikulska, Inmaculada Heras, Alina Ferster, Anne Kozijn, Peter J. Shaw, Marián Angeles Cuesta Casas, Montserrat Batlle Massana, Zeynep Arzu Yegin, Marta González-Vicent, Hélène Labussière-Wallet, Goda Choi, Lourdes Vázquez, Jan Styczyński, Jaime Sanz, Gloria Tridello, Ariadna Pérez, David Navarro, Nicola Polverelli, Nicole M. A. Blijlevens
Rok vydání: 2021
Předmět:
PNEUMONIA
Male
viruses
medicine.medical_treatment
seasonal human coronavirus
Hematopoietic stem cell transplantation
medicine.disease_cause
DISEASE
law.invention
Coronavirus OC43
Human
CLINICAL CHARACTERISTICS
law
Coronavirus 229E
Human
Risk Factors
Immunology and Allergy
Child
Respiratory Tract Infections
NL63 INFECTIONS
Coronavirus
OUTCOMES
Respiratory tract infections
SYNCYTIAL VIRUS
Hazard ratio
Hematopoietic Stem Cell Transplantation
virus diseases
upper and lower respiratory tract disease
HCoV-NL63
HCoV-229E
respiratory system
Middle Aged
Intensive care unit
Hospitalization
immunocompromised
surgical procedures
operative
Infectious Diseases
medicine.anatomical_structure
AcademicSubjects/MED00290
Child
Preschool
Cohort
Female
Seasons
Coronavirus Infections
Rare cancers Radboud Institute for Health Sciences [Radboudumc 9]
allogeneic hematopoietic stem cell transplantation
community-acquired respiratory virus
HCoV-HKU1
HCoV-OC43
immunodeficiency score index
multiplex PCR assay
Adult
medicine.medical_specialty
Adolescent
DIAGNOSIS
CHINA
Betacoronavirus
All institutes and research themes of the Radboud University Medical Center
stomatognathic system
Internal medicine
medicine
Major Article
RHINOVIRUS
Humans
Aged
Retrospective Studies
business.industry
Infant
Transplantation
Coronavirus NL63
Human
PARAINFLUENZA VIRUS
business
Respiratory tract
Zdroj: Journal of Infectious Diseases, 223(9), 1564-1575. OXFORD UNIV PRESS INC
The Journal of Infectious Diseases
Journal of Infectious Diseases
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
instname
The Journal of Infectious Diseases, 223, 1564-1575
The Journal of Infectious Diseases, 223(9), 1564-1575. Oxford University Press
The Journal of Infectious Diseases, 223, 9, pp. 1564-1575
ISSN: 1537-6613
0022-1899
Popis: Background Little is known about characteristics of seasonal human coronaviruses (HCoVs) (NL63, 229E, OC43, and HKU1) after allogeneic stem cell transplantation (allo-HSCT). Methods This was a collaborative Spanish and European bone marrow transplantation retrospective multicenter study, which included allo-HSCT recipients (adults and children) with upper respiratory tract disease (URTD) and/or lower respiratory tract disease (LRTD) caused by seasonal HCoV diagnosed through multiplex polymerase chain reaction assays from January 2012 to January 2019. Results We included 402 allo-HSCT recipients who developed 449 HCoV URTD/LRTD episodes. Median age of recipients was 46 years (range, 0.3–73.8 years). HCoV episodes were diagnosed at a median of 222 days after transplantation. The most common HCoV subtype was OC43 (n = 170 [38%]). LRTD involvement occurred in 121 episodes (27%). HCoV infection frequently required hospitalization (18%), oxygen administration (13%), and intensive care unit (ICU) admission (3%). Three-month overall mortality after HCoV detection was 7% in the whole cohort and 16% in those with LRTD. We identified 3 conditions associated with higher mortality in recipients with LRTD: absolute lymphocyte count Conclusions Seasonal HCoV after allo-HSCT may involve LRTD in many instances, leading to a significant morbidity.
Databáze: OpenAIRE
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