Adiponectin and negative mood in healthy premenopausal and postmenopausal women

Autor: Elizabeth A. Springer, Tanja C. Adam, Elissa E. Epel, Imke Schamarek, Peter J. Havel
Rok vydání: 2010
Předmět:
Aging
Medical and Health Sciences
Behavioral Neuroscience
Norepinephrine
Endocrinology
Catecholamines
Mood
Medicine
Adiposity
Depression
Diabetes
Middle Aged
Biological Sciences
Irritable Mood
Postmenopause
Mental Health
Health
Female
Adiponectin
hormones
hormone substitutes
and hormone antagonists
Adult
medicine.medical_specialty
Epinephrine
Adipokine
Stress
Behavioral Science & Comparative Psychology
Young Adult
Insulin resistance
Clinical Research
Internal medicine
Diabetes mellitus
Behavioral and Social Science
Humans
Obesity
Metabolic and endocrine
Aged
Endocrine and Autonomic Systems
business.industry
Contraception/Reproduction
nutritional and metabolic diseases
medicine.disease
Estrogen
Cross-Sectional Studies
Premenopause
Psychological
business
Body mass index
Stress
Psychological
Hormone
Zdroj: Hormones and behavior, vol 58, iss 5
Adam, Tanja; Schamarek, Imke; Springer, Elizabeth A; Havel, Peter J; & Epel, Elissa E. (2010). Adiponectin and negative mood in healthy premenopausal and postmenopausal women.. Hormones and behavior, 58(5), 699-704. doi: 10.1016/j.yhbeh.2010.05.006. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/3nc7321h
Popis: Negative mood and stress are associated with cardiovascular and metabolic disease. There are likely many physiological mechanisms underlying the poor health outcomes. The relationship of psychological states (negative mood, life stress, and stress-responsive hormones) and adiponectin, an adipokine that promotes insulin sensitivity, was investigated in two separate studies. The two groups of participants included 52 healthy, premenopausal women, and 63 postmenopausal women with a range of stress levels. The relationship between adiponectin and psychological state (perceived stress and negative mood) was examined cross-sectionally in both groups of participants, but also prospectively (1 year later) in the group of postmenopausal women. In premenopausal women, negative mood and nocturnal urinary epinephrine were significantly related to adiponectin, independent of BMI. In postmenopausal women, negative mood was not associated with adiponectin cross-sectionally, but negative mood was a significant predictor for lower levels of adiponectin 1 year later, independent of initial adiponectin concentrations and changes in body mass index. Lastly, having a depressive disorder was related to lower adiponectin. As adiponectin levels are associated with insulin resistance, obesity, and diabetes mellitus, these findings suggest there may be an adiponectin-mediated pathway explaining in part how negative mood affects metabolic health. Mechanistic studies are needed to explore this potential relationship further.
Databáze: OpenAIRE
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