Increased Circulating Anti-inflammatory Cells in Marathon-trained Runners
| Autor: | Imran Sunesara, Gailen D. Marshall, Kristina E. Rehm |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Adult
CD4-Positive T-Lymphocytes Male medicine.medical_specialty medicine.drug_class medicine.medical_treatment T cell education Physical Therapy Sports Therapy and Rehabilitation Biology T-Lymphocytes Regulatory Anti-inflammatory Running Flow cytometry Interleukin 21 Immune system T-Lymphocyte Subsets Internal medicine Healthy control medicine Humans Orthopedics and Sports Medicine Physical Education and Training medicine.diagnostic_test T-Lymphocytes Helper-Inducer Middle Aged Interleukin 10 Cross-Sectional Studies Cytokine Endocrinology medicine.anatomical_structure Immunology Physical Endurance Female Disease Susceptibility human activities |
| Zdroj: | International Journal of Sports Medicine. 36:832-836 |
| ISSN: | 1439-3964 0172-4622 |
| Popis: | Exercise training can alter immune function. Marathon training has been associated with an increased susceptibility to infectious diseases and an increased activity of inflammatory-based diseases, but the precise mechanisms are unknown. The purpose of this study was to compare levels of circulating CD4 + T cell subsets in the periphery of marathon-trained runners and matched non-marathon controls. 19 recreational marathoners that were 4 weeks from running a marathon and 19 demographically-matched healthy control subjects had the percentage of CD4 + T cell subpopulations (T helper 1, T helper 2, T helper 1/T helper 2 ratio, regulatory T cells, CD4 + IL10 + , and CD4 + TGFβ + (Transforming Growth Factor-beta) measured by flow cytometry. Marathon-trained runners had significantly less T helper 1 and regulatory T cells and significantly more T helper 2, CD4 + IL10 + , and TGFβ + cells than the control subjects. The alterations in the percentage of T helper 1 and T helper 2 cells led to a significantly lower T helper 1/T helper 2 ratio in the marathon-trained runners. These data suggest that endurance-based training can increase the number of anti-inflammatory cells. This may be a potential mechanism for the increased incidence of both infectious and inflammatory diseases observed in endurance athletes. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|