Increase of follicular helper T cells skewed toward a Th1 profile in CVID patients with non-infectious clinical complications
| Autor: | Delphine Turpin, Patrick Blanco, Marie Parrens, Adeline Furudoï, Dorothée Duluc, Jean-François Viallard |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male 0301 basic medicine Receptors CXCR3 Sarcoidosis Immunology CXCR3 Autoimmune Diseases 03 medical and health sciences Th2 Cells Follicular phase medicine Humans Immunology and Allergy Enteropathy B cell B-Lymphocytes biology business.industry Lymphopoiesis Common variable immunodeficiency Germinal center T-Lymphocytes Helper-Inducer Middle Aged Th1 Cells Germinal Center medicine.disease Lymphoproliferative Disorders Intestinal Diseases Common Variable Immunodeficiency 030104 developmental biology medicine.anatomical_structure Case-Control Studies biology.protein Th17 Cells Female Antibody business Complication Immunologic Memory Spleen |
| Zdroj: | Clinical Immunology. 197:130-138 |
| ISSN: | 1521-6616 |
| Popis: | Common variable immunodeficiency (CVID) is characterized by low levels of circulating immunoglobulins and defects in B cell maturation leading to an increased susceptibility to infections. Some patients develop complications such as autoimmune diseases, enteropathy, and lymphoproliferation, resulting in higher morbidity and mortality. Follicular helper T (Tfh) cells are specialized in helping B cell differentiation into Ig-producing cells. Three subsets have been described, namely non B-cell helper Tfh1 and the two B-helper cell subsets Tfh2 and Tfh17. We determined that circulating Tfh cells were elevated in CVID patients and skewed toward a Tfh1 profile. Interestingly, elevated levels of Tfh1 cells were significant only in patients harboring non-infectious complications regardless of the type of complication and inversely correlated with switched memory B cells. Moreover, CXCR3+ cells are increased in splenic CVID germinal centers. Our observations suggest that the altered balance in Tfh subsets in CVID is linked to a more severe disease. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect