Local recurrence after mesorectal excision for rectal cancer
| Autor: | Knut Nygaard, O. C. Lunde, Arild Nesbakken, Tom Mala, O. Westerheim |
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| Rok vydání: | 2002 |
| Předmět: |
Adult
Male medicine.medical_specialty Colorectal cancer medicine.medical_treatment Urology Rectum Adenocarcinoma Disease-Free Survival Sampling Studies medicine Humans Minimally Invasive Surgical Procedures Prospective Studies Prospective cohort study Survival rate Colectomy Aged Neoplasm Staging Proportional Hazards Models Aged 80 and over Rectal Neoplasms business.industry Proportional hazards model Incidence Biopsy Needle Hazard ratio General Medicine Middle Aged medicine.disease Total mesorectal excision Surgery Survival Rate Treatment Outcome medicine.anatomical_structure Oncology Female Neoplasm Recurrence Local business Follow-Up Studies |
| Zdroj: | European Journal of Surgical Oncology (EJSO). 28:126-134 |
| ISSN: | 0748-7983 |
| Popis: | Aims: Controversy still exists about the optimal surgical treatment of rectal cancer. The main purpose of the present study was to compare local recurrence (LR) rates after mesorectal excision (ME) and conventional surgery (CS) technique. Methods: All rectal cancer patients from a defined catchment area were included. Outcome after ME in the period 1993–1999 (n=161) was compared with the outcome after CS (n=217) in the period 1983–1992. Partial ME (PME) was the routine in upper, and total ME the routine in mid- and low rectal cancer. The follow-up programmes were identical, and the median observation times very similar (37 and 38 months) in the two periods. Five-year actuarial LR rate and survival were estimated using the Kaplan–Meier method, and adjustment for prognostic factors was performed with Cox regression analysis. Results: Total LR rate after R0 resection was 7.7% crude and 9% 5 year actuarial in the ME period, as compared with 16.0% crude and 24% actuarial in the CS period (P=0.02). Cox regression analyses confirmed these differences with a hazard ratio of 0.40 for ME vs CS (P=0.02). Isolated LR rate was 2% after ME and 8% after CS. Five-year actuarial total LR rate after rectal resection with curative intent was 11% after ME and 27% after CS (P |
| Databáze: | OpenAIRE |
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