Sex differences in the association of body mass index with symptoms and cognitive deficits in Chinese patients with chronic schizophrenia
| Autor: | Mei Hong Xiu, Mi Ma, Xiang Yang Zhang, Chang Wei Wei, Ying Qi Chen |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
China Repeatable Battery for the Assessment of Neuropsychological Status Cross-sectional study Pathogenesis Neuropsychological Tests Article Body Mass Index lcsh:RC321-571 03 medical and health sciences Cellular and Molecular Neuroscience Cognition 0302 clinical medicine Humans Medicine Cognitive Dysfunction Prospective Studies Prospective cohort study lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry Biological Psychiatry Language Psychiatric Status Rating Scales Sex Characteristics business.industry medicine.disease 030227 psychiatry Psychiatry and Mental health Cross-Sectional Studies Schizophrenia Female Schizophrenic Psychology Age of onset Psychiatric disorders business Body mass index 030217 neurology & neurosurgery Sex characteristics Clinical psychology |
| Zdroj: | Translational Psychiatry, Vol 10, Iss 1, Pp 1-8 (2020) Translational Psychiatry |
| ISSN: | 2158-3188 |
| DOI: | 10.1038/s41398-020-0717-x |
| Popis: | Accumulating studies have revealed gender differences in many aspects of schizophrenia (SZ), including obesity and cognitive function. The relationship between obesity and cognitive impairment in SZ has been studied before; however, the results are inconsistent. This study was designed to examine the sex differences in the relationship between body mass index (BMI) and cognitive deficits in Chinese patients with chronic SZ, which have not been investigated yet. 176 chronic patients with SZ (male/female = 108/68) and 200 controls (male/female = 120/80) were enrolled to compare the sex differences in cognitive functions measured by the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS), BMI, and their associations. The clinical symptoms were evaluated using the positive and negative syndrome scales (PANSS). Our results showed that male patients had lower BMI and more negative symptoms but fewer positive symptoms than female patients (all p R2 = 0.22. These findings revealed significant sex differences in BMI, cognitive dysfunctions and their association in SZ. Nonetheless, these results should only be considered as preliminary because of the cross-sectional design, which will deserve further replication in first-episode patients using a prospective longitudinal design. |
| Databáze: | OpenAIRE |
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