A historical view of estrogen effect on arterial endothelial healing: From animal models to medical implication
| Autor: | Coralie Fontaine, Melissa Buscato, Morgane Davezac, Jean-François Arnal, Rana Zahreddine, Natalia F. Smirnova, Marine Adlanmerini, Daniel Henrion, Muriel Laffargue, Françoise Lenfant |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Genetically modified mouse
Cell type Estradiol Endothelium business.industry medicine.drug_class Estrogen receptor Estrogens Atherosclerosis Cell biology Endothelial stem cell Mice medicine.anatomical_structure Selective estrogen receptor modulator Estrogen Models Animal Animals Medicine Endothelium Vascular Cardiology and Cardiovascular Medicine business Receptor |
| Zdroj: | Atherosclerosis. 338:30-38 |
| ISSN: | 0021-9150 |
| Popis: | Endothelial barrier integrity is required for maintaining vascular homeostasis and fluid balance between the circulation and surrounding tissues. In contrast, abnormalities of endothelial cell function and loss of the integrity of the endothelial monolayer constitute a key step in the onset of atherosclerosis. Endothelial erosion is directly responsible for thrombus formation and cardiovascular events in about one-third of the cases of acute coronary syndromes. Thus, after endothelial injury, the vascular repair process is crucial to restore endothelial junctions and rehabilitate a semipermeable barrier, preventing the development of vascular diseases. Endothelial healing can be modulated by several factors. In particular, 17β-estradiol (E2), the main estrogen, improves endothelial healing, reduces neointimal accumulation of smooth muscle cells and atherosclerosis in several animal models. The aim of this review is to highlight how various experimental models enabled the progress in the cellular and molecular mechanisms underlying the accelerative E2 effect on arterial endothelial healing through the estrogen receptor (ER) α, the main receptor mediating the physiological effects of estrogens. We first summarize the different experimental procedures used to reproduce vascular injury. We then provide an overview of how the combination of transgenic mouse models impacting ERα signalling with pharmacological tools demonstrated the pivotal role of non-genomic actions of ERα in E2-induced endothelial repair. Finally, we describe recent advances in the action of selective estrogen receptor modulators (SERMs) on this beneficial vascular effect, which surprisingly involves different cell types and activates different ERα subfunctions compared to E2. |
| Databáze: | OpenAIRE |
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