Effect of a synthetic cannabinoid agonist on the proliferation and invasion of gastric cancer cells
| Autor: | Ki Hwan Han, Xiang Shu Xian, In Seok Lee, Jae Myung Park, In-Sik Chung, Hyeyeon Park, Yu Kyung Cho, Myung-Gyu Choi, Sang Woo Kim |
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| Rok vydání: | 2010 |
| Předmět: |
Agonist
Cannabinoid receptor medicine.drug_class Morpholines medicine.medical_treatment Down-Regulation Apoptosis Naphthalenes Pharmacology Biochemistry Flow cytometry Receptor Cannabinoid CB1 Stomach Neoplasms Cell Line Tumor medicine Humans Neoplasm Invasiveness Receptor Molecular Biology Cell Proliferation DNA Primers Base Sequence medicine.diagnostic_test Reverse Transcriptase Polymerase Chain Reaction Chemistry digestive oral and skin physiology Cell Biology Flow Cytometry Immunohistochemistry Benzoxazines Cell culture Cancer cell Cannabinoid |
| Zdroj: | Journal of Cellular Biochemistry. |
| ISSN: | 1097-4644 0730-2312 |
| DOI: | 10.1002/jcb.22540 |
| Popis: | Although cannabinoids are associated with antineoplastic activity in a number of cancer cell types, the effect in gastric cancer cells has not been clarified. In the present study, we investigated the effects of a cannabinoid agonist on gastric cancer cell proliferation and invasion. The cannabinoid agonist WIN 55,212-2 inhibited the proliferation of human gastric cancer cells in a dose-dependent manner and that this effect was mediated partially by the CB(1) receptor. We also found that WIN 55,212-2 induced apoptosis and down-regulation of the phospho-AKT expression in human gastric cancer cells. Furthermore, WIN 55,212-2 treatment inhibited the invasion of gastric cancer cells, and down-regulated the expression of MMP-2 and VEGF-A through the cannabinoid receptors. Our results open the possibilities in using cannabinoids as a new gastric cancer therapy. |
| Databáze: | OpenAIRE |
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