Risk factors for loco-regional recurrence in breast cancer patients: a retrospective study
| Autor: | Tomás Merino, Francisco Acevedo, César Sánchez, Eugenio Vinés, Mauricio Camus, Alejandra Villaroel, Teresa Ip, Francisco Domínguez, Lidia Medina |
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| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
law.invention subtype 03 medical and health sciences breast cancer 0302 clinical medicine Breast cancer Randomized controlled trial law medicine 030212 general & internal medicine Stage (cooking) Univariate analysis business.industry General surgery Medical record Retrospective cohort study medicine.disease predictors Oncology 030220 oncology & carcinogenesis Population study local recurrence Positive Surgical Margin business Research Paper regional recurrence |
| Zdroj: | Oncotarget |
| ISSN: | 1949-2553 |
| Popis: | // Tomas Merino 1, * , Teresa Ip 1, * , Francisco Dominguez 2 , Francisco Acevedo 1 , Lidia Medina 1 , Alejandra Villaroel 3 , Mauricio Camus 2 , Eugenio Vines 1 and Cesar Sanchez 1 1 Department of Hematology-Oncology, Pontificia Universidad Catolica de Chile, Santiago, Chile 2 Department of Surgery, Pontificia Universidad Catolica de Chile, Santiago, Chile 3 Department of Pathology, Pontificia Universidad Catolica de Chile, Santiago, Chile * These authors contributed equally to this work Correspondence to: Tomas Merino, email: tmerino@med.puc.cl Keywords: breast cancer; local recurrence; regional recurrence; predictors; subtype Received: January 29, 2018 Accepted: June 23, 2018 Published: July 13, 2018 ABSTRACT Background: Although fairly uncommon, loco-regional recurrence in breast cancer (BC) has major consequences for the patient. Several predictors for locoregional have been previously reported from large randomized clinical trials mainly from Europe & North America; data from other geographical areas are somewhat scarce. Here we performed a retrospective review of medical records in a single academic center in Chile, searching for predictors of breast tumor recurrence. Results: Median patient follow up was 61 months, 5 year overall survival (OS) rate was 94.2% (95% CI 93–95.3). We found that 108 out of 2,754 (5.3%) patients had loco-regional recurrence. The 2-year loco-regional control was 98% (95% CI 97.3–98.7) and 5-year was 94% (95% CI 92.6–95.4). Univariate analysis showed a correlation between recurrence and being |
| Databáze: | OpenAIRE |
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