HSA—Coated Magnetic Nanoparticles for MRI-Guided Photodynamic Cancer Therapy
| Autor: | Michael A. Grin, V.A. Naumenko, Raisa I. Yakubovskaya, P.V. Ostroverkhov, Alexander G. Majouga, A. S. Semkina, Artem M. Abakumov, Vladimir P. Chekhonin, Stepan Vodopyanov, E. A. Plotnikova, Maxim A. Abakumov |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Colorectal cancer
medicine.medical_treatment Pharmaceutical Science lcsh:RS1-441 Photodynamic therapy 02 engineering and technology 010402 general chemistry 01 natural sciences Article lcsh:Pharmacy and materia medica chemistry.chemical_compound medicine polycyclic compounds Photosensitizer medicine.diagnostic_test Chemistry iron oxide nanoparticles Magnetic resonance imaging 021001 nanoscience & nanotechnology Human serum albumin medicine.disease eye diseases 0104 chemical sciences Permeability (electromagnetism) human serum albumin Drug delivery 0210 nano-technology therapeutics Iron oxide nanoparticles medicine.drug Biomedical engineering MRI |
| Zdroj: | Pharmaceutics Volume 10 Issue 4 Pharmaceutics, Vol 10, Iss 4, p 284 (2018) |
| ISSN: | 1999-4923 |
| DOI: | 10.3390/pharmaceutics10040284 |
| Popis: | Background: Photodynamic therapy (PDT) is a promising technique for cancer treatment however, low tissue permeability for irradiating light and insufficient photosensitizer (PS) accumulation in tumors limit its clinical potential. Nanoparticles are engineered to improve selective drug delivery to tumor sites, but its accumulation is highly variable between tumors and patients. Identifying PS accumulation peak in a personalized manner is crucial for therapeutic outcome. Magnetic nanoparticles (MNPs) provide opportunity for tracking drug accumulation in dynamics using non-invasive magnetic resonance imaging (MRI). The purpose of the study was to evaluate MNP loaded with PS as a theranostic tool for treating cancer in mice xenograft colon cancer models. Methods: MNPs coated with human serum albumin (HSA) were loaded with bacteriochlorine a. MRI, atomic emission spectroscopy (AES) and fluorescent imaging were used to study MNP and drug accumulation rates and dynamics in CT26 tumors. Tumor growth curves were evaluated in animals that received PDT at different time points upon MNP systemic injection. Results: Peak MNP accumulation in tumors was detected by MRI 60 min post injection (pi) and the data were verified by AES and fluorescent imaging. Up to 17% of injected dose/g of tissue was delivered to malignant tissues 24 h after injection. Consistent with MRI predicted drug accumulation peak PDT performed 60 min after intravenous injection was more efficient in inhibiting tumor growth than treatment scheduled 30 min and 240 min pi. Conclusions: PS loading on HAS-coated MNPs is a perspective approach to increase drug delivery to tumor site. Tracking for MNP accumulation by MRI can be used to predict drug concentration peak in tumors and to adjust PDT time scheduling for improved antitumor response. |
| Databáze: | OpenAIRE |
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