Eculizumab for Salvage Treatment of Refractory Antibody-Mediated Rejection in Kidney Transplant Patients: Case Reports
| Autor: | Berna Yelken, A. Turkmen, M. Uzunalan, E. Demiralp, M. Kalayoglu, N. Gorgulu, Burak Kocak, S. Gorcin, Emre Arpali, C. Karatas |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Graft Rejection medicine.medical_specialty Necrosis medicine.medical_treatment Salvage therapy Antibodies Monoclonal Humanized Refractory Biopsy medicine Humans Kidney transplantation Salvage Therapy Transplantation medicine.diagnostic_test business.industry Eculizumab medicine.disease Kidney Transplantation Surgery Monoclonal Female Plasmapheresis medicine.symptom business medicine.drug |
| Zdroj: | Transplantation Proceedings. 45:1022-1025 |
| ISSN: | 0041-1345 |
| Popis: | Antibody-mediated rejection (AMR) in a group of preoperatively desensitized patients may follow a dreadful course and result in loss of the transplanted kidney. In several cases, conventional therapies including plasmapheresis, intravenous immunoglobulin, and anti-CD 20 therapy can resolve AMR successfully. But in some cases the load of immunoglobulins that can activate complement cascade may submerge the routine desensitization therapy and result in the formation of membrane attack complexes. Eculizumab, monoclonal antibody against C5, was reported to be an option in cases with severe AMR that are resistant to conventional therapy. Here, we present two cases of acute-onset AMR in preoperatively desensitized patients. Eculizumab was used as a salvage agent in addition to conventional therapy. Given the bad prognosis for renal transplants displaying acute injury progressing rapidly to cortical necrosis on the biopsy, the prompt use of eculizumab could have the advantage of immediate effects by stopping cellular injury. This can provide a therapeutic window to allow conventional treatment modalities to be effective and prevent early graft loss. |
| Databáze: | OpenAIRE |
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