Intravenous Lipid Emulsions in the Prevention and Treatment of Liver Disease in Intestinal Failure
| Autor: | Fedja A. Rochling |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Review Gastroenterology Liver disease 0302 clinical medicine parental nutrition-associated liver disease (PNALD) Risk Factors Intestinal failure Medicine Child Infusions Intravenous Nutrition and Dietetics Cholestasis Liver Diseases mixed fish oil-containing lipid emulsions (MFO IVLE) Fish oil Pathophysiology intravenous lipid emulsions (IVLE) fish oil lipid emulsions (FO IVLE) parenteral nutrition-associated cholestasis (PNAC) essential fatty acid deficiency (EFAD) Toxicity 030211 gastroenterology & hepatology lcsh:Nutrition. Foods and food supply Cohort study Adult medicine.medical_specialty Fat Emulsions Intravenous medium-chain triglycerides (MCT) parenteral nutrition (PN) lcsh:TX341-641 intestinal failure-associated liver disease (IFALD) 03 medical and health sciences Fish Oils Internal medicine Animals Humans soybean lipid emulsions (SB IVLE) 030109 nutrition & dietetics Adult patients business.industry Infant Newborn Infant polyunsaturated fatty acid (PUFA) medicine.disease Soybean Oil Intestinal Diseases Parenteral nutrition business Food Science |
| Zdroj: | Nutrients Nutrients, Vol 13, Iss 895, p 895 (2021) |
| ISSN: | 2072-6643 |
| Popis: | The development of intestinal failure-associated liver disease (IFALD) in pediatric and adult patients on parenteral nutrition is usually multifactorial in nature due to nutritional and non-nutritional causes. The role of lipid therapy as a contributing cause is well-established with the pathophysiological pathways now better understood. The review focuses on risk factors for IFALD development, biological effects of lipids, lipid emulsions and the mechanisms of lipid toxicity observed in laboratory animals followed by a synopsis of clinical studies in pediatric and adult patients. The introduction of fish oil-based lipid emulsions that provide partial or complete lipid replacement therapy has resulted in resolution of IFALD that had been associated with soybean oil-based therapy. Based on case reports and cohort studies in pediatric and adult patients who were at risk or developed overt liver disease, we now have more evidence that an early switch to partial or complete fish oil–based lipid therapy should be implemented in order to successfully halt and reverse IFALD. |
| Databáze: | OpenAIRE |
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