Improvement of conjunctival cytological grade and tear production in Ankylosing Spondylitis patients under TNF inhibitors: a long-term follow-up
| Autor: | C. G. S. Saad, Eloisa Bonfa, Ruth Miyuki Santo, Priscila Novaes, Jozélio Freire de Carvalho, Nadia E. Aikawa, Fany Solange Usuba, Julio C. B. Moraes, Milton Ruiz Alves |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Adult Male medicine.medical_specialty Adolescent Long term follow up Corneal diseases lcsh:Medicine Disease Systemic inflammation Gastroenterology Severity of Illness Index Tear production Article 03 medical and health sciences Young Adult 0302 clinical medicine Quality of life Conjunctival diseases Internal medicine medicine Humans Spondylitis Ankylosing Prospective Studies lcsh:Science Ankylosing spondylitis Multidisciplinary business.industry lcsh:R Middle Aged medicine.disease 030104 developmental biology Concomitant Case-Control Studies Tears 030221 ophthalmology & optometry lcsh:Q Tumor necrosis factor alpha Dry Eye Syndromes Female Tumor Necrosis Factor Inhibitors medicine.symptom business Conjunctiva Follow-Up Studies |
| Zdroj: | Scientific Reports Scientific Reports, Vol 10, Iss 1, Pp 1-7 (2020) |
| ISSN: | 2045-2322 |
| Popis: | Dry eye disease can compromise the patient’s quality of life. Few studies assessed the ocular surface (OS) in Ankylosing Spondylitis (AS) patients. This study aimed to evaluate the clinical and cytological findings of the OS in patients with AS, classify dry eye disease (DED) severity grade and conjunctival impression cytology (IC), and the effects of TNF inhibitors (TNFi) in a one-year follow-up. A baseline (BL) evaluation included 36 AS patients and 39 healthy controls. They fulfilled the Ocular Surface Index Disease questionnaire and underwent the Schirmer I test, break-up time, vital staining, and conjunctival IC. A DED severity grade, as well as IC rating, was applied. Fourteen of these patients received TNFi and analysis of ocular and systemic AS disease parameters occurred at BL and three months (3 M), and 12 months (12 M) after treatment. The AS patients presented a higher frequency of DED (p = 0.01), a worse score of severity (p = 0.001), and a higher frequency of altered IC (p = 0.007) when compared to controls. The 14 patients under TNFi presented an improvement in all the clinical disease activity parameters throughout the one-year treatment (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|