Potentiation of cigarette smoking and radiation evidence from a sputum cytology survey among uranium miners and controls
| Autor: | Lynda Watson, Michael L. Feldstein, Geno Saccomanno, Garner King, Pierre R. Band |
|---|---|
| Rok vydání: | 1980 |
| Předmět: |
Adult
Male Risk Cancer Research medicine.medical_specialty Sputum Cytology Lung Neoplasms Neoplasms Radiation-Induced Time Factors Cumulative Exposure Logistic regression Mining Toxicology Cigarette smoking Internal medicine Atypia Humans Medicine Smoke Cocarcinogenesis business.industry Incidence (epidemiology) Smoking Sputum medicine.disease respiratory tract diseases Occupational Diseases Radon Daughters Oncology Radon Uranium Female business |
| Zdroj: | Cancer. 45:1273-1277 |
| ISSN: | 1097-0142 0008-543X |
| DOI: | 10.1002/1097-0142(19800315)45:6<1273::aid-cncr2820450602>3.0.co;2-# |
| Popis: | To assess the effect of cigarette smoking and of exposure to radon daughters, a prospective survey consisting of periodic sputum cytology evaluation was initiated among 249 underground uranium miners and 123 male controls. Sputum cytology specimens showing moderate atypia, marked atypia, or cancer cells were classified as abnormal. As compared to control smokers, miners who smoke had a significantly higher incidence of abnormal cytology (P = .025). For miner smokers, the observed frequencies of abnormal cytology were linearly related to cumulative exposure to radon daughters and to the number of years of uranium mining. A statistical model relating the probability of abnormal cytology to the risk factors was investigated using a binary logistic regression. The estimated frequency of abnormal cytology was significantly dependent, for controls, on the duration of cigarette smoking, and for miners, on the duration of cigarette smoking and of uranium mining. |
| Databáze: | OpenAIRE |
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