ZikaBase: An integrated ZIKV- Human Interactome Map database
| Autor: | Leimarembi Devi Naorem, Sanathoi Gurumayum, Mathavan Muthaiyan, Amouda Venkatesan, Rahul Brahma, Jeyakodi Gopal |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Zika Virus Infection Viral entry into host cell RNA-Seq Zika Virus Computational biology Biology Interactome Viral Proteins 03 medical and health sciences 030104 developmental biology Human interactome Virology Chlorocebus aethiops Host-Pathogen Interactions Molecular mechanism ZikV Infection Animals Humans Integrated database Databases Protein Vero Cells Gene Protein Binding |
| Zdroj: | Virology. 514:203-210 |
| ISSN: | 0042-6822 |
| Popis: | Re-emergence of ZIKV has caused infections in more than 1.5 million people. The molecular mechanism and pathogenesis of ZIKV is not well explored due to unavailability of adequate model and lack of publically accessible resources to provide information of ZIKV-Human protein interactome map till today. This study made an attempt to curate the ZIKV-Human interaction proteins from published literatures and RNA-Seq data. 11 direct interaction, 12 associated genes are retrieved from literatures and 3742 Differentially Expressed Genes (DEGs) are obtained from RNA-Seq analysis. The genes have been analyzed to construct the ZIKV-Human Interactome Map. The importance of the study has been illustrated by the enrichment analysis and observed that direct interaction and associated genes are enriched in viral entry into host cell. Also, ZIKV infection modulates 32% signal and 27% immune system pathways. The integrated database, ZikaBase has been developed to help the virology research community and accessible at https://test5.bicpu.edu.in . |
| Databáze: | OpenAIRE |
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