Relationship between amiodarone-induced subclinical lung toxicity and Th1/Th2 balance
Autor: | Shioto Yasuda, Yuichiro Yasuda, Keita Odashiro, Toru Maruyama, Tadao Kuruma, Shin ichi Hiramatsu, Mine Harada |
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Rok vydání: | 2007 |
Předmět: |
Adult
Lung Diseases Male medicine.medical_specialty medicine.medical_treatment Administration Oral Amiodarone Antiarrhythmic agent Gastroenterology Interferon-gamma Th2 Cells Internal medicine Medicine Humans Adverse effect Subclinical infection Aged Lung business.industry Odds ratio Middle Aged Th1 Cells Flow Cytometry Cytokine medicine.anatomical_structure Endocrinology Toxicity Ventricular Fibrillation Tachycardia Ventricular Regression Analysis Female Interleukin-4 Cardiology and Cardiovascular Medicine business Anti-Arrhythmia Agents medicine.drug |
Zdroj: | International journal of cardiology. 134(2) |
ISSN: | 1874-1754 |
Popis: | Background Although amiodarone is a potent antiarrhythmic agent, its clinical use is limited by serious lung toxicity. This study investigated the mechanisms of amiodarone-induced lung toxicity from an immunological perspective. Because interferon gamma (IFN-γ: Th1 cytokine) inhibits pulmonary fibroblast proliferation whereas interleukin-4 (IL-4: Th2 cytokine) augments fibroblast growth and collagen production, we hypothesized that amiodarone lung toxicity is related to Th1/Th2 balance. Methods Twenty-six consecutive Japanese patients with ventricular arrhythmias treated with amiodarone were enrolled in this study and were divided into two groups. Group A contained patients demonstrating amiodarone lung toxicity diagnosed by chest X-ray, KL-6 or D LCO ( n =6), whereas group B included patients treated without any adverse effects ( n =20). Th1/Th2 balance was investigated by the ratio of IFN-γ and IL-4 produced by activated peripheral CD4 + T cells. Results Clinical baseline characteristics prior to oral amiodarone did not show any differences between group A and group B except for D LCO (82.0±5.2% vs. 90.8±9.0%, p =0.032) and Th1/Th2 balance (7.98±1.68 vs. 13.34±5.10, p =0.020). This balance was not altered three months after withdrawal of amiodarone in group A and under continued treatment in group B, suggesting patient-specific rather than amiodarone-induced. After starting amiodarone, serum concentration of desethylamiodarone was greater in group A than in group B ( p =0.009) and was inversely proportional to Th1/Th2 ratio ( p =0.013). Multilogistic regression analysis indicated that Th1/Th2 balance was the most powerful indicator of amiodarone lung toxicity ( p =0.046, odds ratio of 0.424). Conclusions Although large cohort is required, the present study indicates that Th1/Th2 balance may influence amiodarone metabolism and may be a powerful indicator of amiodarone-induced subclinical lung toxicity at least in Japanese. |
Databáze: | OpenAIRE |
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