Impact of COAPT trial exclusion criteria in real-world patients undergoing transcatheter mitral valve repair
| Autor: | Roman Pfister, Maria Isabel Körber, Clemens Metze, Christos Iliadis, Stephan Baldus |
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| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty Minnesota 030204 cardiovascular system & hematology Ventricular Function Left 03 medical and health sciences 0302 clinical medicine Internal medicine medicine.artery Mitral valve medicine Humans 030212 general & internal medicine Aged Aged 80 and over Heart Valve Prosthesis Implantation COPD Mitral regurgitation Ejection fraction business.industry MitraClip Mitral Valve Insufficiency Stroke Volume Middle Aged medicine.disease Treatment Outcome Blood pressure medicine.anatomical_structure Heart failure Pulmonary artery Cardiology Mitral Valve Female Cardiology and Cardiovascular Medicine business |
| Zdroj: | International Journal of Cardiology. 316:189-194 |
| ISSN: | 0167-5273 |
| Popis: | Background The generalizability of the COAPT trial results on the benefit of TMVR in patients with secondary mitral regurgitation is unclear. Methods Functional and long-term clinical outcome were examined in 122 consecutive patients with secondary mitral regurgitation and reduced ejection fraction undergoing TMVR. “COAPT-like” patients were defined according to principal COAPT inclusion/exclusion criteria if all of the following was fulfilled: symptomatic mitral regurgitation grade 3+ or more according to American guidelines; left ventricular ejection fraction ≥ 20%, left ventricular end-systolic dimension ≤ 70 mm, estimated pulmonary artery systolic pressure ≤ 70 mmHg, mitral valve orifice area ≥ 4 cm2, no prior mitral valve procedure, no right sided congestive heart failure, no COPD requiring home oxygen therapy and NYHA class less than IVb. Results 51% of 122 patients (mean age 74 ± 10 years, 76% male) showed COAPT-like characteristics. COAPT-like patients showed a significantly lower hazard for the composite endpoint of mortality and heart failure hospitalization (HR 0.51, 95%CI 0.30–0.89, p = .017) during a mean follow-up of 16 ± 6 months, with an estimated 1-year event rate of 20% vs 43%, respectively. The improvement in functional outcomes 6 min walking distance (76 ± 136 m vs. 31 ± 90 m), Minnesota Living with Heart Failure Questionnaire (−6 ± 19 vs. −10 ± 23) and Short Form 36 physical component score (3.8 ± 10 vs. 5.5 ± 11) was similar in COAPT-like and the other patients. Conclusion In this first real world cohort half of the patients undergoing TMVR showed COAPT-like characteristics and these patients showed a substantially better clinical outcome. The mid-term functional benefit was similar in COAPT-like and other patients. |
| Databáze: | OpenAIRE |
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